School of Medicine, University of Tampere, Finland.
J Enzyme Inhib Med Chem. 2013 Apr;28(2):231-9. doi: 10.3109/14756366.2012.700640. Epub 2012 Jul 18.
Carbonic anhydrase III (CA III) is a cytosolic enzyme which is known to be highly expressed in the skeletal muscle and has been recently linked to important roles in several physiological processes.
This review is focused on properties of CA III, including its distribution, function, structure and modulation of enzymatic activity by activators or inhibitors. We also provide some novel data on its expression in murine tissues.
In this article, the most relevant literature on CA III has been covered. New information on the distribution has been obtained by immunohistochemical staining and western blotting.
CA III shows the highest expression in the skeletal muscle and liver. Several other tissues contain lower levels of the enzyme. Activation or inhibition of CA III may offer a novel opportunity to treat some of the diseases linked to the defective expression or function of this enzyme.
碳酸酐酶 III（CA III）是一种细胞溶质酶，已知在骨骼肌中高度表达，并与几种生理过程中的重要作用有关。
本综述重点介绍 CA III 的特性，包括其分布、功能、结构以及通过激活剂或抑制剂对酶活性的调节。我们还提供了其在鼠组织中表达的一些新数据。
本文涵盖了 CA III 最相关的文献。通过免疫组织化学染色和 Western blot 获得了有关分布的新信息。
CA III 在骨骼肌和肝脏中表达最高。其他一些组织含有较低水平的酶。CA III 的激活或抑制可能为治疗与该酶表达或功能缺陷相关的某些疾病提供新的机会。
