CD8 共受体功能的分子决定因素。
The molecular determinants of CD8 co-receptor function.
机构信息
Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
出版信息
Immunology. 2012 Oct;137(2):139-48. doi: 10.1111/j.1365-2567.2012.03625.x.
Abstract
CD8(+) T cells respond to signals mediated through a specific interaction between the T-cell receptor (TCR) and a composite antigen in the form of an epitopic peptide bound between the polymorphic α1 and α2 helices of an MHC class I (MHCI) molecule. The CD8 glycoprotein 'co-receives' antigen by binding to an invariant region of the MHCI molecule and can enhance ligand recognition by up to 1 million-fold. In recent years, a number of structural and biophysical investigations have shed light on the role of the CD8 co-receptor during T-cell antigen recognition. Here, we provide a collated resource for these data, and discuss how the structural and biophysical parameters governing CD8 co-receptor function further our understanding of T-cell cross-reactivity and the productive engagement of low-affinity antigenic ligands.
摘要
CD8(+) T 细胞通过 T 细胞受体 (TCR) 与 MHC Ⅰ类 (MHCI) 分子的多态性 α1 和 α2 螺旋之间结合的表位肽的特定相互作用介导的信号做出反应。CD8 糖蛋白通过与 MHCI 分子的不变区域结合“共同接收”抗原，并且可以增强配体识别多达 100 万倍。近年来，许多结构和生物物理研究揭示了 CD8 共受体在 T 细胞抗原识别过程中的作用。在这里，我们为这些数据提供了一个整理资源，并讨论了控制 CD8 共受体功能的结构和生物物理参数如何进一步了解 T 细胞交叉反应性和低亲和力抗原配体的有效结合。
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