Department of Chemistry, BK21 Program, Polymer Research Institute, Pohang University of Science and Technology (POSTECH) , Pohang , Republic of Korea.
J Drug Target. 2012 Sep;20(8):648-66. doi: 10.3109/1061186X.2012.704634. Epub 2012 Jul 17.
Gene therapy aims to treat human disorders by introducing genetic materials into specific target cells or tissues. Despite the curability for the origIn of diseases by restoring missing functionalities, no technical feasibility of gene therapy has been established due to the lack of safe and efficient gene delivery systems. The emergence of nanotechnology has provided an opportunity to create nanomaterials that are suitable for the biomedical applications. Nanomaterials integrated with cationic polymers offer novel platforms that allow not only easy incorporation of genetic materials through electrostatic interactions but also further modifications to be upgraded to theranostics. In this article, current status of gene delivery utilizing hybrid nanomaterials that are composed of novel nanoplatforms and cationic polymers are highlighted. In particular, different strategies employed for the construction of nanomaterial-polymer hybrids are described.
基因治疗旨在通过将遗传物质引入特定的靶细胞或组织来治疗人类疾病。尽管通过恢复缺失的功能可以治愈疾病的起源，但由于缺乏安全有效的基因传递系统，基因治疗的技术可行性尚未建立。纳米技术的出现为创造适用于生物医学应用的纳米材料提供了机会。与阳离子聚合物结合的纳米材料提供了新的平台，不仅可以通过静电相互作用轻松地掺入遗传物质，而且还可以进一步修饰以升级为治疗诊断学。本文重点介绍了由新型纳米平台和阳离子聚合物组成的混合纳米材料在基因传递中的应用现状。特别地，描述了用于构建纳米材料-聚合物杂化物的不同策略。
