Wang Ting, Wang Sha-sha, Hou Zhi-Guo, Ji Xiao-Ming, Song Zhi-Fang, Jia Xiao-Min, Wang Mei-Lin, Ni Chun-Hui
Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Apr;30(4):246-9.
To explore the role of -1C/T single nucleotide polymorphism within Annexin A5 gene in the genetic susceptibility to coal worker's pneumoconiosis (CWP).
Four hundred and seventy CWP Han chinese patients and 428 Han chinese controls were enclosed in present case-control study. All subjects were exposed to coal dusts. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the -1C/T SNP in Annexin A5 gene for all subjects. The relationship between the -1C/T SNP in Annexin A5 gene and CWP was analyzed.
CT/TT genotype in -1C/T SNP was associated with a significantly decreased risk of CWP, as compared with the CC genotype among subgroups exposed to coal dusts for ≥ 27 years (adjusted OR = 0.65, 95%CI: 0.44 - 0.98, P = 0.039) and patients with CWP at stage II (adjusted OR = 0.55, 95%CI: 0.34 - 0.90, P = 0.028).
The results of present study suggest that the Annexin A5 -1C/T polymorphism may be involved in the development of CWP in Han Chinese coal miners.
探讨膜联蛋白A5基因-1C/T单核苷酸多态性在煤工尘肺（CWP）遗传易感性中的作用。
本病例对照研究纳入470例汉族CWP患者和428例汉族对照。所有受试者均接触煤尘。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测所有受试者膜联蛋白A5基因的-1C/T单核苷酸多态性（SNP）。分析膜联蛋白A5基因-1C/T SNP与CWP的关系。
在接触煤尘≥27年的亚组中（校正OR = 0.65，95%CI：0.44 - 0.98，P = 0.039）以及II期CWP患者中（校正OR = 0.55，95%CI：0.34 - 0.90，P = 0.028），与CC基因型相比，-1C/T SNP的CT/TT基因型与CWP风险显著降低相关。
本研究结果表明，膜联蛋白A5 -1C/T多态性可能参与汉族煤矿工人CWP的发生发展。
