Van Proeyen Karen, Ramaekers Monique, Pischel Ivo, Hespel Peter
Dept. of Biomedical Kinesiology, K.U. Leuven, Leuven, Belgium.
Int J Sport Nutr Exerc Metab. 2012 Aug;22(4):284-91. doi: 10.1123/ijsnem.22.4.284. Epub 2012 Jul 4.
The purpose of this study was to investigate the effect of Opuntia ficus-indica (OFI) cladode and fruit-skin extract on blood glucose and plasma insulin increments due to high-dose carbohydrate ingestion, before and after exercise. Healthy, physically active men (n = 6; 21.0 ± 1.6 years, 78.1 ± 6.0 kg) participated in a double-blind placebo-controlled crossover study involving 2 experimental sessions. In each session, the subjects successively underwent an oral glucose tolerance test at rest (OGTT(R)), a 30-min cycling bout at ~75% VO(2max), and another OGTT after exercise (OGTT(EX)). They received capsules containing either 1,000 mg OFI or placebo (PL) 30 min before and immediately after the OGTT(R). Blood samples were collected before (t₀) and at 30-min intervals after ingestion of 75 g glucose for determination of blood glucose and serum insulin. In OGTT(EX) an additional 75-g oral glucose bolus was administered at t₆₀. In OGTT(R), OFI administration reduced the area under the glucose curve (AUC(GLUC)) by 26%, mainly due to lower blood glucose levels at t₃₀ and t₆₀ (p < .05). Furthermore, a higher serum insulin concentration was noted after OFI intake at baseline and at t₃₀ (p < .05). In OGTT(EX), blood glucose at t₆₀ was ~10% lower in OFI than in PL, which resulted in a decreased AUC(GLUC) (-37%, p < .05). However, insulin values and AUC(INS) were not different between OFI and PL. In conclusion, the current study shows that OFI extract can increase plasma insulin and thereby facilitate the clearance of an oral glucose load from the circulation at rest and after endurance exercise in healthy men.
本研究的目的是调查食用仙人掌（OFI）茎和果皮提取物对运动前后因高剂量碳水化合物摄入引起的血糖和血浆胰岛素升高的影响。健康、有体育活动的男性（n = 6；21.0±1.6岁，78.1±6.0 kg）参与了一项双盲安慰剂对照交叉研究，该研究包括2个实验阶段。在每个阶段，受试者依次进行静息状态下的口服葡萄糖耐量试验（OGTT(R)）、在约75%最大摄氧量下进行30分钟的骑行运动，以及运动后的另一次OGTT（OGTT(EX)）。在OGTT(R)之前和之后30分钟，他们分别服用含有1000毫克OFI或安慰剂（PL）的胶囊。在摄入75克葡萄糖之前（t₀）和之后每隔30分钟采集血样，用于测定血糖和血清胰岛素。在OGTT(EX)中，在t₆₀时额外给予75克口服葡萄糖推注。在OGTT(R)中，服用OFI使葡萄糖曲线下面积（AUC(GLUC)）降低了26%，主要是由于t₃₀和t₆₀时血糖水平较低（p <.05）。此外，在基线和t₃₀时，服用OFI后血清胰岛素浓度较高（p <.05）。在OGTT(EX)中，OFI组t₆₀时的血糖比PL组低约10%，这导致AUC(GLUC)降低（-37%，p <.05）。然而，OFI组和PL组的胰岛素值和AUC(INS)没有差异。总之，当前研究表明，OFI提取物可以增加血浆胰岛素，从而在健康男性静息状态和耐力运动后促进循环中口服葡萄糖负荷的清除。
