Wöllner J, Neisius A, Hampel C, Thüroff J W
Klinik und Poliklinik für Urologie, Universitätsmedizin der Universität Mainz, Langenbeckstraße 1, 55131 Mainz, Deutschland.
Urologe A. 2012 Oct;51(10):1432-7. doi: 10.1007/s00120-012-2969-4.
Extracorporeal magnetic innervation (ExMI) is a non-invasive therapy for treatment of urinary incontinence (UI). The aim of the current study was to evaluate the efficacy of ExMI in a prospective case series.
Over a period of 1.5 years 63 consecutive patients with a clinically and urodynamically confirmed diagnosis of urinary incontinence were enrolled. All patients requested an additional non-surgical therapy option and the ExMI system (Neo control™, Kitalpha, USA) was used. The therapy consisted of 12 treatment sessions two to three times a week. Primary outcome parameter was reduction of the number of pads per 24 h and secondary outcome parameters were patient satisfaction, adverse events and duration of the therapeutic effect.
A total of 63 patients (57 male and 6 female), mean age 68±7.1 years were recruited. After completion a significant (p=0.001) reduction of the number of pads used per 24 h was observed (from 5.4±3.7 to 2.7±2.5) which persisted after a median follow-up of 12.5 months (2.3±2.2 pads per 24 h). Also patients suffering from UI after prostatectomy revealed a significant (p=0.001) reduction in the number of pads from 4.8±2.9 to 2.6±2.6 with persistence at 2.5±2.5 at follow-up. Transient, self-limiting perineal pain in three patients was the only reported side effect.
The ExMI procedure is an additional non-invasive therapy option for patients with urinary incontinence. However, sham-controlled studies are required to corroborate the therapy effect.
体外磁刺激神经支配（ExMI）是一种治疗尿失禁（UI）的非侵入性疗法。本研究的目的是在前瞻性病例系列中评估ExMI的疗效。
在1.5年的时间里，连续纳入63例经临床和尿动力学确诊为尿失禁的患者。所有患者均要求增加一种非手术治疗方案，并使用了ExMI系统（Neo control™，Kitalpha，美国）。治疗包括每周两到三次，共12次治疗。主要结局参数是每24小时使用的尿垫数量减少，次要结局参数是患者满意度、不良事件和治疗效果持续时间。
共招募了63例患者（57例男性和6例女性），平均年龄68±7.1岁。完成治疗后，观察到每24小时使用的尿垫数量显著减少（p=0.001）（从5.4±3.7减少到2.7±2.5），在中位随访12.5个月后仍持续（每24小时2.3±2.2个尿垫）。前列腺切除术后患有尿失禁的患者每24小时使用的尿垫数量也显著减少（p=0.001），从4.8±2.9减少到2.6±2.6，随访时为2.5±2.5。仅报告了3例患者出现短暂的、自限性的会阴部疼痛这一副作用。
ExMI程序是尿失禁患者的另一种非侵入性治疗选择。然而，需要进行假对照研究来证实治疗效果。
