超亲电脒二阳离子：三氟甲磺酸根阴离子的脱烷基化反应。
Superelectrophilic amidine dications: dealkylation by triflate anion.
机构信息
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.
出版信息
Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8516-9. doi: 10.1002/anie.201202990. Epub 2012 Jul 13.
PMID:22807275
Abstract
Superelectrophiles: Formamides were designed that when treated with triflic anhydride would be transformed into superelectrophilic amidine dications. These dications were so electrophilic that they underwent in situ dealkylation by the triflate anion (see scheme; Tf = trifluoromethanesulfonyl). DFT calculations were used to determine the mechanistic details of the dealkylation reaction.
摘要
超强亲电试剂
设计了一种甲酰胺，用三氟甲磺酸酐处理后，会转化为超强亲电的脒二阳离子。这些二阳离子具有极强的亲电性，会被三氟甲磺酸根阴离子原位去烷基化（见方案；Tf = 三氟甲磺酸基）。DFT 计算用于确定去烷基化反应的机理细节。
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