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基于活性的 LMP7 近红外荧光探针：活细胞中免疫蛋白酶体的化学蛋白质组学工具。

Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.

机构信息

Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.

出版信息

Chembiochem. 2012 Sep 3;13(13):1899-903. doi: 10.1002/cbic.201200307. Epub 2012 Jul 17.

DOI:10.1002/cbic.201200307
PMID:22807337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3431601/
Abstract

Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.

摘要

探索未知

免疫蛋白酶体是组成型蛋白酶体的一种替代形式，与许多病理状态有关，如癌症和自身免疫性疾病。为了了解免疫蛋白酶体在细胞中的作用，研究人员开发了第一个免疫蛋白酶体特异性近红外荧光探针。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/489dbd1aaae8/nihms399790f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/0b133348fbb4/nihms399790f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/66c283599c66/nihms399790f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/3f7981cfe68d/nihms399790f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/3ff2313e1425/nihms399790f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/e55d1722423a/nihms399790f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/489dbd1aaae8/nihms399790f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/0b133348fbb4/nihms399790f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/66c283599c66/nihms399790f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/3f7981cfe68d/nihms399790f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/3ff2313e1425/nihms399790f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/e55d1722423a/nihms399790f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3f/3431601/489dbd1aaae8/nihms399790f6.jpg

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本文引用的文献

1
A critical role for the inducible proteasomal subunits LMP7 and MECL1 in cytokine production by activated murine splenocytes.诱导型蛋白酶体亚基 LMP7 和 MECL1 在激活的鼠脾细胞细胞因子产生中的关键作用。
Pharmacology. 2012;89(3-4):117-26. doi: 10.1159/000336335. Epub 2012 Mar 7.
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Immunoproteasome-specific inhibitors and their application.免疫蛋白酶体特异性抑制剂及其应用。
Methods Mol Biol. 2012;832:391-401. doi: 10.1007/978-1-61779-474-2_27.
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Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.免疫和组成型蛋白酶体晶体结构揭示了底物和抑制剂特异性的差异。
Cell. 2012 Feb 17;148(4):727-38. doi: 10.1016/j.cell.2011.12.030.
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Immune and non-immune functions of the immunoproteasome.免疫蛋白酶体的免疫和非免疫功能。
Front Biosci (Landmark Ed). 2012 Jan 1;17(5):1904-16. doi: 10.2741/4027.
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Imaging proteins inside cells with fluorescent tags.用荧光标记物对细胞内的蛋白质进行成像。
Trends Biotechnol. 2012 Jan;30(1):8-16. doi: 10.1016/j.tibtech.2011.08.002. Epub 2011 Sep 15.
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The immunoproteasome: an emerging therapeutic target.免疫蛋白酶体：一个新兴的治疗靶点。
Curr Top Med Chem. 2011 Dec;11(23):2923-30. doi: 10.2174/156802611798281348.
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A bright approach to the immunoproteasome: development of LMP2/β1i-specific imaging probes.一种针对免疫蛋白酶体的新方法：LMP2/β1i 特异性成像探针的开发。
Bioorg Med Chem. 2012 Jan 15;20(2):607-13. doi: 10.1016/j.bmc.2011.06.039. Epub 2011 Jul 7.
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Second generation proteasome inhibitors: carfilzomib and immunoproteasome-specific inhibitors (IPSIs).第二代蛋白酶体抑制剂：卡非佐米和免疫蛋白酶体特异性抑制剂（IPSIs）。
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Molecular basis of the selectivity of the immunoproteasome catalytic subunit LMP2-specific inhibitor revealed by molecular modeling and dynamics simulations.通过分子建模和动力学模拟揭示免疫蛋白酶体催化亚基 LMP2 特异性抑制剂选择性的分子基础。
J Phys Chem B. 2010 Sep 30;114(38):12333-9. doi: 10.1021/jp1058098.
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Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress.免疫蛋白酶体在干扰素诱导的氧化应激下维持蛋白质平衡。
Cell. 2010 Aug 20;142(4):613-24. doi: 10.1016/j.cell.2010.07.036.