基于活性的 LMP7 近红外荧光探针：活细胞中免疫蛋白酶体的化学蛋白质组学工具。
Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.
机构信息
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
出版信息
Chembiochem. 2012 Sep 3;13(13):1899-903. doi: 10.1002/cbic.201200307. Epub 2012 Jul 17.
Abstract
Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.
摘要
探索未知
免疫蛋白酶体是组成型蛋白酶体的一种替代形式，与许多病理状态有关，如癌症和自身免疫性疾病。为了了解免疫蛋白酶体在细胞中的作用，研究人员开发了第一个免疫蛋白酶体特异性近红外荧光探针。
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