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2-{N-[2-(2,4-二氯苯氧基)乙酰基]-4-[(4,6-二甲氧基嘧啶-2-基)氧基]苯胺基}丙酸甲酯

Methyl 2-{N-[2-(2,4-dichloro-phen-oxy)acet-yl]-4-[(4,6-dimeth-oxy-pyrimidin-2-yl)-oxy]anilino}propano-ate.

作者信息

Ning Lihong, Peng Hao, He Hongwu

机构信息

Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China .

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2012 Jul 1;68(Pt 7):o2046. doi: 10.1107/S1600536812025494. Epub 2012 Jun 13.

Abstract

In the title mol-ecule, C(24)H(23)Cl(2)N(3)O(7), the central benzene ring forms dihedral angles of 65.71 (1) and 44.42 (1)° with the pyrimidine ring and the terminal benzene ring, respectively. In the crystal, molecules are linked via C-H⋯O hydrogen bonds.

摘要

在标题分子C₂₄H₂₃Cl₂N₃O₇中,中心苯环与嘧啶环和末端苯环分别形成65.71 (1)°和44.42 (1)°的二面角。在晶体中,分子通过C—H⋯O氢键相连。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b5/3393314/6405c770c235/e-68-o2046-fig1.jpg

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本文引用的文献

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Synthesis and antitumor activity of ureas containing pyrimidinyl group.含嘧啶基的脲类化合物的合成及抗肿瘤活性。
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Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55. doi: 10.1107/S090744490804362X. Epub 2009 Jan 20.
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Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.

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