Villani L G, Dalla Valle R, Rubini P
Istituto di Patologia Speciale Chirurgica, Università di Parma.
Minerva Chir. 1990 Aug;45(15-16):1029-33.
Forty-one surgical patients at risk of deep venous thrombosis (DVT) were treated with defibrotide (400 mg/b.i.d./i.v.) or with heparin (5000 UI/t.i.d./s.c.). Neither DVT nor pulmonary embolism was evidenced. In the heparin group the healing rate was longer and during the first three days bleeding from the surgical wound was more pronounced. In particular one patient of the heparin group had to interrupt the treatment for haemorrhage.
41名有深静脉血栓形成（DVT）风险的外科手术患者接受了去纤苷（400mg/每日两次/静脉注射）或肝素（5000单位/每日三次/皮下注射）治疗。未发现深静脉血栓形成或肺栓塞。肝素组的愈合时间更长，且在头三天手术伤口出血更明显。特别是肝素组有一名患者因出血不得不中断治疗。
