Cześcik Agnieszka, Dunal Milena, Trzcińska Agnieszka, Siennicka Joanna
Zakład Wirusologii NIZP-PZH w Warszawie.
Med Dosw Mikrobiol. 2012;64(1):73-8.
The increase of measles incidence in Poland was recently observed. Furthermore, the analysis of routine serological tests performed in the department of virology, NIPH-NIH revealed, that nearly half of young people (20-30 years old) have no antibodies against measles virus. The paper presents results of IgG specific for measles virus prevalence in the sera of vaccinated and unvaccinated subjects, which aimed to make the selection of groups for immunological memory research.
Total of 100 persons were examined based on results of determination of the presence of IgG anti-MeV: 26 people born before and 74 born after 1972 year. From this group, 55 participants were selected for further study and divided into 3 groups (1) subjects born before 1972, unvaccinated against measles and seropositive as a result of natural infection, (2) subjects born after 1972, vaccinated against measles but seronegative or with traces ofanti-MeV IgG presence, (3) subjects born after 1972 seropositive due to vaccination. Selected persons are subject to further examinations include determination the number of leukocytes and lymphocytes profile.
The level of anty-MeV IgG antibodies in subjects after natural infection was significantly higher compared to levels obtained by vaccinations. No significant differences in the immunological parameters which could influence on immune response were observed.
Obtained results lead to search other factors that may affect the weak postvaccinal humoral response.
最近观察到波兰麻疹发病率有所上升。此外，国家公共卫生研究所 - 国家卫生研究院病毒学部门进行的常规血清学检测分析显示，近一半的年轻人（20 - 30岁）没有针对麻疹病毒的抗体。本文展示了接种和未接种疫苗的受试者血清中麻疹病毒特异性IgG的流行情况结果，旨在选择用于免疫记忆研究的群体。
根据抗麻疹病毒IgG的检测结果，共检查了100人：26人出生于1972年之前，74人出生于1972年之后。从该组中，选择了55名参与者进行进一步研究，并分为3组：（1）1972年之前出生、未接种麻疹疫苗且因自然感染血清呈阳性的受试者；（2）1972年之后出生、接种过麻疹疫苗但血清呈阴性或有微量抗麻疹病毒IgG存在的受试者；（3）1972年之后出生因接种疫苗血清呈阳性的受试者。选定的人员接受进一步检查，包括白细胞数量和淋巴细胞谱的测定。
自然感染后的受试者中抗麻疹病毒IgG抗体水平明显高于接种疫苗后的水平。未观察到可能影响免疫反应的免疫参数有显著差异。
获得的结果促使人们寻找可能影响疫苗接种后体液免疫反应较弱的其他因素。
