Honda K, Negoro H, Higuchi T, Takano S
Department of Physiology, Fukui Medical School, Japan.
Neurosci Lett. 1990 Nov 13;119(2):167-70. doi: 10.1016/0304-3940(90)90825-t.
In urethane-anesthetized male rats extracellular recordings were obtained from neurosecretory cells in the supraoptic nucleus (SON) while each of electrical stimulation and local osmotic stimulation produced by pressure injection of hypertonic saline was applied to the median preoptic nucleus (MnPO) or to the medial septal nucleus (MS). Electrical stimulation of the MnPO produced orthodromic excitation or initial inhibition followed by strong excitation in most SON cells (59/61), and local osmotic stimulation of the MnPO excited majority of cells (39/51). On the contrary, local osmotic stimulation of the MS did not excite SON cells, although electrical stimulation excited all the cells (5/5). The results suggest that the MnPO is one of the osmosensitive sites controlling electrical activity of SON neurosecretory cells.
在氨基甲酸乙酯麻醉的雄性大鼠中，从视上核（SON）的神经分泌细胞获得细胞外记录，同时将电刺激以及由高渗盐水压力注射产生的局部渗透刺激分别施加到视前正中核（MnPO）或内侧隔核（MS）。对MnPO进行电刺激在大多数SON细胞（59/61）中产生顺向兴奋或初始抑制，随后是强烈兴奋，对MnPO进行局部渗透刺激使大多数细胞（39/51）兴奋。相反，对MS进行局部渗透刺激并未使SON细胞兴奋，尽管电刺激使所有细胞（5/5）兴奋。结果表明，MnPO是控制SON神经分泌细胞电活动的渗透压敏感位点之一。
