Bigbee J W, Yu D S, Yu R K
Department of Anatomy, Virginia Commonwealth University/Medical College of Virginia, Richmond 23298.
Neurosci Lett. 1990 Nov 13;119(2):179-81. doi: 10.1016/0304-3940(90)90828-w.
During the period of active myelination, the CNS of the F1 hybrid mouse, derived from DBA/2J (D2) and C57BL/6J (B6) parental strains, displays levels of myelin-specific markers which are greater than in either parent. This so-called hypermyelination has been attributed to hybrid vigor or heterosis. Morphometric comparison of the optic nerves of F1 and parental strains revealed that the F1 contains larger myelinated axons and fewer premyelinated axons. These observations suggest that, compared with its parental strains, the F1 hybrid shows an early onset and accelerated rate of myelination.
在活跃髓鞘形成期，源自DBA/2J（D2）和C57BL/6J（B6）亲本品系的F1杂交小鼠的中枢神经系统，其髓鞘特异性标志物水平高于任一亲本。这种所谓的髓鞘过度形成归因于杂种优势。对F1和亲本品系的视神经进行形态测量比较发现，F1含有更大的有髓轴突和更少的前髓鞘轴突。这些观察结果表明，与亲本品系相比，F1杂交小鼠表现出髓鞘形成的早期发作和加速速率。
