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Prostate cancer--uncertainty and a way forward.

作者信息

Thompson Ian M, Tangen Catherine M

出版信息

N Engl J Med. 2012 Jul 19;367(3):270-1. doi: 10.1056/NEJMe1205012.

DOI:10.1056/NEJMe1205012
PMID:22808963
Abstract
摘要

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Prostate cancer--uncertainty and a way forward.前列腺癌——不确定性与前行之路。
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Radical prostatectomy versus observation for prostate cancer.
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Radical prostatectomy does not improve survival compared to observation for localised prostate cancer in a prospective randomised trial.在一项前瞻性随机试验中，与对局限性前列腺癌进行观察相比，根治性前列腺切除术并不能提高生存率。
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Radical prostatectomy versus watchful waiting in early prostate cancer.根治性前列腺切除术与早期前列腺癌的观察等待。
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Loss of cytoplasmic survivin expression is an independent predictor of poor prognosis in radically operated prostate cancer patients.细胞质生存素表达缺失是根治性前列腺癌患者预后不良的独立预测因子。
Cancer Med. 2020 Feb;9(4):1409-1418. doi: 10.1002/cam4.2773. Epub 2020 Jan 1.
2
Expression of CCCTC-binding factor (CTCF) is linked to poor prognosis in prostate cancer.CCCTC 结合因子（CTCF）的表达与前列腺癌的预后不良有关。
Mol Oncol. 2020 Jan;14(1):129-138. doi: 10.1002/1878-0261.12597. Epub 2019 Nov 29.
3
Upregulation of SPDEF is associated with poor prognosis in prostate cancer.
SPDEF的上调与前列腺癌的不良预后相关。
Oncol Lett. 2019 Nov;18(5):5107-5118. doi: 10.3892/ol.2019.10885. Epub 2019 Sep 19.
4
Down-Regulation of S100A8 is an Independent Predictor of PSA Recurrence in Prostate Cancer Treated by Radical Prostatectomy.S100A8 下调是根治性前列腺切除术后 PSA 复发的独立预测因子。
Neoplasia. 2019 Sep;21(9):872-881. doi: 10.1016/j.neo.2019.07.003. Epub 2019 Aug 2.
5
A nuclear shift of GSK3β protein is an independent prognostic factor in prostate cancer.GSK3β蛋白的核转位是前列腺癌的一个独立预后因素。
Oncotarget. 2019 Mar 1;10(18):1729-1744. doi: 10.18632/oncotarget.26739.
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Aberrant expression of the microtubule-associated protein tau is an independent prognostic feature in prostate cancer.微管相关蛋白 tau 的异常表达是前列腺癌的一个独立预后特征。
BMC Cancer. 2019 Mar 1;19(1):193. doi: 10.1186/s12885-019-5390-1.
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Upregulation of centromere protein F is linked to aggressive prostate cancers.着丝粒蛋白F的上调与侵袭性前列腺癌相关。
Cancer Manag Res. 2018 Nov 9;10:5491-5504. doi: 10.2147/CMAR.S165630. eCollection 2018.
8
Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer.Y 盒结合蛋白 1（YB-1）的上调和核转位与 ERG 阴性前列腺癌的不良预后相关。
Sci Rep. 2017 May 17;7(1):2056. doi: 10.1038/s41598-017-02279-x.
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Family with sequence similarity 13C (FAM13C) overexpression is an independent prognostic marker in prostate cancer.序列相似性家族13成员C（FAM13C）过表达是前列腺癌的一个独立预后标志物。
Oncotarget. 2017 May 9;8(19):31494-31508. doi: 10.18632/oncotarget.16357.
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Overexpression of the A Disintegrin and Metalloproteinase ADAM15 is linked to a Small but Highly Aggressive Subset of Prostate Cancers.去整合素和金属蛋白酶ADAM15的过表达与一小部分侵袭性很强的前列腺癌相关。
Neoplasia. 2017 Apr;19(4):279-287. doi: 10.1016/j.neo.2017.01.005. Epub 2017 Mar 8.