Laboratory of Applied Material Science, Department of Agricultural Biology, National Institute of Agricultural Science and Technology, RDA, Suwon, Korea.
Am J Chin Med. 2012;40(4):795-800. doi: 10.1142/S0192415X12500590.
The aim of this study was to access the irritant properties of bee venom (BV) after its application to skin and eye mucous membranes of the rabbit. The animals were also observed for clinical signs and mortality after the application of the test material. Six animals were used for the skin irritation test and nine rabbits for the eye irritation test. The acute BV application to the rabbit skin revealed no appreciable clinical signs throughout the observation period of 72 h and there was no mortality seen. In the eye irritation test, eye reactions were read and graded 24, 48, 72, 96 and 168 h after BV treatment. No changes in the cornea, iris or conjunctivae were observed at all time points of observations. Based on the present findings, it can be concluded that the irritation potential of BV is negligible.
本研究旨在评估蜂毒（BV）应用于兔皮肤和眼黏膜后的刺激性。在应用受试物后，还观察了动物的临床症状和死亡率。皮肤刺激性试验使用了 6 只动物，眼刺激性试验使用了 9 只兔子。急性 BV 应用于兔皮肤，在 72 小时的观察期内未出现明显的临床症状，也未观察到死亡。在眼刺激性试验中，在 BV 处理后 24、48、72、96 和 168 小时分别观察眼反应并进行分级。在整个观察期间，角膜、虹膜或结膜均未观察到任何变化。基于目前的研究结果，可以得出结论，BV 的刺激性潜力可以忽略不计。
