Department of Internal Medicine, Institute of Gerontology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Aging Cell. 2012 Dec;11(6):921-32. doi: 10.1111/j.1474-9726.2012.00864.x. Epub 2012 Aug 27.
Nutrient allocation and usage plays an important part in regulating the onset and progression of age-related functional declines. Here, we describe a heterozygous mutation in Drosophila (dFatp) that alters nutrient distribution and multiple aspects of physiology. dFatp mutants have increased lifespan and stress resistance, altered feeding behavior and fat storage, and increased mobility. Concurrently, mutants experience impairment of cardiac function. We show that endurance exercise reverses increased lipid storage in the myocardium and the deleterious cardiac function conferred by dFatp mutation. These findings establish a novel conserved genetic target for regulating lifespan and physiology in aging animals. These findings also highlight the importance of varying exercise conditions in assessing aging functions of model organisms.
营养分配和利用在调节与年龄相关的功能衰退的发生和进展中起着重要作用。在这里，我们描述了果蝇（dFatp）中的一个杂合突变，该突变改变了营养分布和多个生理方面。dFatp 突变体的寿命和抗应激能力增加，摄食行为和脂肪储存改变，运动能力增强。同时，突变体的心脏功能受损。我们表明，耐力运动逆转了心肌中脂质储存的增加以及 dFatp 突变带来的有害心脏功能。这些发现为调节衰老动物的寿命和生理提供了一个新的保守遗传靶标。这些发现还强调了在评估模式生物的衰老功能时，改变运动条件的重要性。
