School of Pharmacy, University of Wisconsin at Madison, 777 Highland Avenue, Madison, WI 53705, USA.
Expert Rev Proteomics. 2012 Jun;9(3):267-80. doi: 10.1586/epr.12.20.
Prion diseases are a unique family of fatal neurodegenerative diseases caused by abnormal folding of normal cellular prion proteins in the brain. Due to the high risk of prion disease transmission and the lack of effective treatment to cure or delay the disease progression, prion diseases pose a serious threat to public health. To control and prevent prion diseases, an early diagnosis is urgently needed. Proteomic analysis has emerged as a powerful technology to decipher biological and pathophysiological processes and identify protein biomarkers indicative of disease. In this article, the authors review the use of the latest proteomic technologies for the identification of promising prion disease biomarkers, the challenges that exist in biomarker development pipelines and the new directions for utilizing proteomics for future biomarker discovery in the context of prion disease diagnostics.
朊病毒病是由大脑中正常细胞朊病毒蛋白异常折叠引起的一组独特的致命神经退行性疾病。由于朊病毒病传播的高风险和缺乏有效的治疗方法来治愈或延缓疾病进展，朊病毒病对公共健康构成严重威胁。为了控制和预防朊病毒病，迫切需要早期诊断。蛋白质组学分析已成为一种强大的技术，可以用于破译生物学和病理生理学过程，并鉴定出预示疾病的蛋白质生物标志物。本文作者综述了最新蛋白质组学技术在鉴定有希望的朊病毒病生物标志物方面的应用，探讨了生物标志物开发管道中存在的挑战，以及在未来利用蛋白质组学进行朊病毒病诊断背景下的生物标志物发现的新方向。
