Martin P L, Yen S S, Burnier A M, Hermann H
JAMA. 1979 Dec 14;242(24):2699-700.
Systemic absorption and sustained effects of two estrogen vaginal cream preparations (Premarin and Estrace) were measured in 29 postmenopausal women receiving daily applications. With both preparations, vaginal absorption of estrogens into the systemic circulation was rapid, efficient, and sustained. It is apparent that estrogen vaginal cream preparations, as widely used in clinical practice for their local effects on the vaginal mucosa, actually result in sustained high estrogen levels in the systemic circulation. The vaginal route shows promise when systemic estrogen therapy is indicated, but is dangerous when estrogen is contraindicated.
在29名每日使用两种雌激素阴道乳膏制剂（倍美力和雌二醇）的绝经后女性中，测量了其全身吸收情况和持续效果。对于这两种制剂，雌激素从阴道吸收进入体循环的过程迅速、高效且持续。显然，雌激素阴道乳膏制剂在临床实践中因其对阴道黏膜的局部作用而被广泛使用，但实际上会导致体循环中雌激素水平持续升高。当需要进行全身雌激素治疗时，经阴道途径显示出前景，但当雌激素禁忌时则很危险。
