Department of Geosciences, Georgia State University, Atlanta, GA, USA.
Trop Med Int Health. 2012 Aug;17(8):1005-13. doi: 10.1111/j.1365-3156.2012.03036.x. Epub 2012 Jul 19.
To assess the geographical distribution of melioidosis contamination sources and the association between the location of melioidosis cases and positive sampling sites for Burkholderia pseudomallei in Taiwan.
Data on the location of melioidosis cases from 2002 to 2011 were combined with the geographical distribution of B. pseudomallei as indicated by the detection of specific flagella gene products measured from 2005 to 2011. Temporal and spatial analyses were used to determine the incidence, cluster shifts and associations between the two datasets.
Melioidosis cases clustered in two 'hot-spot' areas with incidence rates that were significantly higher than in neighbouring towns. The incidence rates in the northern area gradually decreased, while the rates in the southern area increased and were temporally associated with the appearance of B. pseudomallei-specific flagella genes in water samples.
Melioidosis hot-spot areas were present in Taiwan. Water contaminated with B. pseudomallei serves as a potential transmission vehicle and is correlated with an increase in melioidosis cases; this correlation was stronger than that for B. pseudomallei-contaminated soil.
评估台湾地区类鼻疽污染来源的地理分布，以及类鼻疽病例的位置与 2005 年至 2011 年间检测到的伯克霍尔德氏菌特定鞭毛基因产物阳性采样点之间的关系。
将 2002 年至 2011 年类鼻疽病例的位置数据与 2005 年至 2011 年检测到的 B. pseudomallei 的地理分布相结合。采用时空分析方法确定两组数据集的发病率、聚类转移和相关性。
类鼻疽病例聚集在两个“热点”地区，发病率明显高于邻近城镇。北部地区的发病率逐渐下降，而南部地区的发病率增加，并与水中检出的 B. pseudomallei 特异性鞭毛基因的出现呈时间相关。
台湾存在类鼻疽热点地区。受 B. pseudomallei 污染的水是一种潜在的传播媒介，与类鼻疽病例的增加有关，其相关性强于受 B. pseudomallei 污染的土壤。
