Kondo K
Jpn Circ J. 1979 Sep;43(9):837-42. doi: 10.1253/jcj.43.837.
The effects of isoproterenol, dibutyryl cyclic AMP, theophylline, and angiotensin II upon tonin release were examined by incubation of rat submaximllary gland slices. Isoproterenol, dibutyryl cyclic AMP, and theophylline stimulated tonin release. Propranolol inhibited the effect of isoproterenol. Angiotensin II by itself did not inhibit tonin release, but it suppressed the increase in tonin release produced by isoproterenol. These results suggest that the tonin stimulating effect of isoproterenol is due, at least in part, to a direct stimulation of beta-receptor upon the submaxillary glands and that cyclic AMP system may play a role as an intracellular mediator of this action. Angiotensin II, which is formed directly from a natural protein substrate by tonin, is suggested to inhibit tonin sectetion in some situations.
通过孵育大鼠下颌下腺切片，研究了异丙肾上腺素、二丁酰环磷腺苷、茶碱和血管紧张素II对紧张素释放的影响。异丙肾上腺素、二丁酰环磷腺苷和茶碱刺激紧张素释放。普萘洛尔抑制异丙肾上腺素的作用。血管紧张素II本身并不抑制紧张素释放，但它抑制了异丙肾上腺素引起的紧张素释放增加。这些结果表明，异丙肾上腺素对紧张素的刺激作用至少部分是由于直接刺激下颌下腺的β受体，并且环磷腺苷系统可能作为该作用的细胞内介质发挥作用。由紧张素直接从天然蛋白质底物形成的血管紧张素II被认为在某些情况下抑制紧张素分泌。
