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选择性微创冠状动脉搭桥术:分流还是环扎闭塞?评估围手术期左前降支分流对心肌损伤的保护作用。一项前瞻性随机研究。

Elective minimally invasive coronary artery bypass: shunt or tournique occlusion? Assessment of a protective role of perioperative left anterior descending shunting on myocardial damage. A prospective randomized study.

作者信息

Sorm Zdenek, Vojacek Jan, Cermakova Eva, Pudil Radek, Stock Ulrich A, Harrer Jan

机构信息

Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Sokolska 581, 50005, Hradec Kralove, Czech Republic.

出版信息

J Cardiothorac Surg. 2012 Jul 18;7:69. doi: 10.1186/1749-8090-7-69.

Abstract

BACKGROUND

To determine impact of intraluminal-left anterior descending shunt to prevent myocardial damage in minimally invasive coronary artery bypass.

METHODS

38 patients were randomly assigned to external tournique occlusion (n = 19) or intraluminal-left anterior descending shunt group (n= 19). Blood samples for cardiac troponin T were collected at 30 minutes prior to, 6 and 24 hours after surgery.

RESULTS

One patient in external tournique occlusion and two patients in intraluminal-left anterior descending shunt group were excluded from futher analysis due to preoperative cardiac troponin T level above the 99th-percentile. Postoperatively, each six patients in external tournique occlusion (33.3%) and intraluminal-left anterior descending shunt (35.3%) group were above the 99th-percentile. Two patients from each group (external tournique occlusion group 11.1% vs. intraluminal-left anterior descending shunt group 11.8%) had peak values above 10-% coeficient of variation cutoff (p = 1). There were no significant differences in between both groups at all studied timepoints.

CONCLUSION

There was no protective effect of intraluminal shunting on myocardial damage compared to short-term tournique occlusion. It is upon the surgeon's discretion which method may preferrably be used to achieve a bloodless field in grafting of the non-occluded left anterior descending in minimally invasive coronary artery bypass.

摘要

背景

确定在微创冠状动脉旁路移植术中使用左前降支腔内分流术预防心肌损伤的效果。

方法

38例患者被随机分为体外阻断组(n = 19)和左前降支腔内分流组(n = 19)。在手术前30分钟、术后6小时和24小时采集心肌肌钙蛋白T血样。

结果

由于术前心肌肌钙蛋白T水平高于第99百分位数,体外阻断组的1例患者和左前降支腔内分流组的2例患者被排除在进一步分析之外。术后,体外阻断组和左前降支腔内分流组各有6例患者(分别为33.3%和35.3%)高于第99百分位数。每组各有2例患者(体外阻断组为11.1%,左前降支腔内分流组为11.8%)峰值高于10-%变异系数临界值(p = 1)。在所有研究时间点,两组之间均无显著差异。

结论

与短期阻断相比,腔内分流术对心肌损伤没有保护作用。在微创冠状动脉旁路移植术中,对于非阻塞性左前降支进行移植时,采用哪种方法能更好地实现无血视野,由外科医生自行决定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfad/3487851/843a650d5f07/1749-8090-7-69-1.jpg

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