Guo Hong-Xiang, Zhang Jian-Jiang, Shi Pei-Pei, Fu Shu-Qin, Zhang Li-Guo, Wang Miao, Lu Feng-Xia
Department of Pediatrics, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2012 Jul;14(7):506-9.
To study the difference in clinico-pathological features between IgA nephropathy (IgAN) and Henoch-Schonlein purpura nephritis (HSPN) in children.
The medical data of 103 children with HSPN and 61 children with IgAN were retrospectively studied.
There were no significant differences in age, sex and disease course between the HSPN and IgAN groups (P>0.05). Clinical classification demonstrated that more severe conditions were found in the IgAN group than in the HSPN group and gross hematuria was more common in the IgAN group (P<0.05). Serum creatinine and cholesterol levels were higher in the IgAN group than in the HSPN group (P<0.05). Fibrinogen-related antigen deposition was more common in the HSPN group, while complement 3(C3) deposition was more common in the IgAN group. Interstitial fibrosis, tubular casts and tubular inflammatory infiltration were also more common in the IgAN group (P<0.05).
Significant clinico-pathological differences can be found between HSPN and IgAN in children, and these differences do not support a one disease entity hypothesis.
研究儿童IgA肾病（IgAN）和过敏性紫癜性肾炎（HSPN）临床病理特征的差异。
回顾性研究103例HSPN患儿和61例IgAN患儿的医学资料。
HSPN组和IgAN组在年龄、性别和病程方面无显著差异（P>0.05）。临床分类显示，IgAN组病情比HSPN组更严重，肉眼血尿在IgAN组更常见（P<0.05）。IgAN组血清肌酐和胆固醇水平高于HSPN组（P<0.05）。纤维蛋白原相关抗原沉积在HSPN组更常见，而补体3（C3）沉积在IgAN组更常见。间质纤维化、肾小管管型和肾小管炎性浸润在IgAN组也更常见（P<0.05）。
儿童HSPN和IgAN之间存在显著的临床病理差异，这些差异不支持单一疾病实体假说。
