免疫球蛋白缺乏症：DiGeorge 综合征的 B 淋巴细胞方面。
Immunoglobulin deficiencies: the B-lymphocyte side of DiGeorge Syndrome.
机构信息
Division of Allergy Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
出版信息
J Pediatr. 2012 Nov;161(5):950-3. doi: 10.1016/j.jpeds.2012.06.018. Epub 2012 Jul 17.
PMID:22809661
Abstract
DiGeorge syndrome is associated with a T-lymphocyte immunodeficiency. The prevalence of hypogammaglobulinemia has not been reported. We found that 3% of patients with DiGeorge syndrome were receiving immunoglobulin replacement therapy and 6% of patients over the age of 3 years had hypogammaglobulinemia. We conclude that DiGeorge syndrome is associated with significant humoral immune deficiency.
摘要
DiGeorge 综合征与 T 淋巴细胞免疫缺陷有关。低丙种球蛋白血症的患病率尚未报道。我们发现，3%的 DiGeorge 综合征患者正在接受免疫球蛋白替代治疗，6%的 3 岁以上患者存在低丙种球蛋白血症。我们的结论是，DiGeorge 综合征与严重的体液免疫缺陷有关。
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