Schatzberg A F, Samson J A, Rothschild A J, Luciana M M, Bruno R F, Bond T C
Harvard Medical School, Boston, Massachusetts.
Psychiatr Clin North Am. 1990 Dec;13(4):633-49.
Methodologic issues pertinent to the study of depression secondary to anxiety are reviewed. Data on the frequency and temporal sequence of comorbid DSM-III-R anxiety and depressive disorders in a sample from the McLean Hospital Depression Research Facility are presented. Patients with major depression secondary to anxiety are compared with major depressed patients without anxiety on a variety of demographic and clinical variables. Conceptual and practical frameworks are developed for assessing and understanding comorbidity and secondary depression.
