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International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations.儿童和成人人群中腺病毒血清型 5、26、35 和 48 的国际血清流行病学研究。
Vaccine. 2011 Jul 18;29(32):5203-9. doi: 10.1016/j.vaccine.2011.05.025. Epub 2011 May 25.
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Adenovirus-based vaccines: comparison of vectors from three species of adenoviridae.腺病毒载体疫苗：三种腺病毒科病毒载体的比较。
J Virol. 2010 Oct;84(20):10522-32. doi: 10.1128/JVI.00450-10. Epub 2010 Aug 4.
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Mucosal trafficking of vector-specific CD4+ T lymphocytes following vaccination of rhesus monkeys with adenovirus serotype 5.黏膜途径中载体特异性 CD4+T 淋巴细胞在恒河猴接种腺病毒血清型 5 后的迁移。
J Virol. 2010 Oct;84(19):9810-6. doi: 10.1128/JVI.01157-10. Epub 2010 Aug 4.
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Upregulating CD59: a new strategy for protection of neurons from complement-mediated degeneration.上调 CD59：保护神经元免受补体介导的退化的新策略。
Pharmacogenomics J. 2010 Feb;10(1):12-9. doi: 10.1038/tpj.2009.52. Epub 2009 Nov 3.
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Adenovirus receptors: implications for tropism, treatment and targeting.腺病毒受体：对嗜性、治疗和靶向作用的影响
Rev Med Virol. 2009 May;19(3):165-78. doi: 10.1002/rmv.612.
6
Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial.一种细胞介导免疫HIV-1疫苗的疗效评估（STEP研究）：一项双盲、随机、安慰剂对照的概念验证试验。
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7
Magnitude and phenotype of cellular immune responses elicited by recombinant adenovirus vectors and heterologous prime-boost regimens in rhesus monkeys.重组腺病毒载体和异源初免-加强免疫方案在恒河猴中引发的细胞免疫反应的强度和表型。
J Virol. 2008 May;82(10):4844-52. doi: 10.1128/JVI.02616-07. Epub 2008 Mar 12.
8
Adenovirus serotype 5 hexon mediates liver gene transfer.腺病毒5型六邻体介导肝脏基因转移。
Cell. 2008 Feb 8;132(3):397-409. doi: 10.1016/j.cell.2008.01.016.
9
Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D.来自B和D亚组的六种罕见血清型重组腺病毒疫苗载体的比较血清阳性率和免疫原性。
J Virol. 2007 May;81(9):4654-63. doi: 10.1128/JVI.02696-06. Epub 2007 Feb 28.
10
CD46 is a cellular receptor for group B adenoviruses.CD46是B组腺病毒的细胞受体。
Nat Med. 2003 Nov;9(11):1408-12. doi: 10.1038/nm952. Epub 2003 Oct 19.

腺病毒血清型 26 利用 CD46 作为主要细胞受体，在恒河猴接种后仅短暂激活 T 淋巴细胞。

Adenovirus serotype 26 utilizes CD46 as a primary cellular receptor and only transiently activates T lymphocytes following vaccination of rhesus monkeys.

机构信息

Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

出版信息

J Virol. 2012 Oct;86(19):10862-5. doi: 10.1128/JVI.00928-12. Epub 2012 Jul 18.

DOI:10.1128/JVI.00928-12
PMID:22811531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3457266/
Abstract

The cellular receptor utilized by adenovirus serotype 26 (Ad26) has remained unclear. Here we show that Ad26 transduction is CD46-dependent and is efficiently blocked by anti-CD46 but not anti-CAR antibodies, demonstrating that Ad26 utilizes CD46 as a primary cellular receptor. Moreover, following Ad26 vaccination of rhesus monkeys, we did not observe sustained activation of peripheral or mucosal vector-specific CD4(+) T lymphocytes. These data contribute to our understanding of Ad26 as a candidate vaccine vector.

摘要

腺病毒血清型 26（Ad26）所利用的细胞受体仍不清楚。在这里，我们表明 Ad26 的转导依赖于 CD46，并且可以被抗 CD46 但不是抗 CAR 抗体有效阻断，这表明 Ad26 将 CD46 用作主要的细胞受体。此外，在恒河猴接种 Ad26 疫苗后，我们没有观察到外周或粘膜载体特异性 CD4(+)T 淋巴细胞的持续激活。这些数据有助于我们了解 Ad26 作为候选疫苗载体。