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Comparison of the convergent receptor utilization of a retargeted feline leukemia virus envelope with a naturally-occurring porcine endogenous retrovirus A.比较重定向的猫白血病病毒包膜与天然存在的猪内源性逆转录病毒 A 的收敛受体利用
Virology. 2012 Jun 5;427(2):118-26. doi: 10.1016/j.virol.2012.02.012. Epub 2012 Mar 8.
2
Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins.通过使用新型改良的逆转录病毒糖蛋白靶向进入生长抑素受体，该糖蛋白以与野生型病毒糖蛋白相当的水平递呈基因。
J Virol. 2012 Jan;86(1):373-81. doi: 10.1128/JVI.05411-11. Epub 2011 Oct 19.
3
Coupling of receptor interference and a host-dependent post-binding entry deficiency in a gammaretroviral envelope protein.包膜蛋白中受体重组干扰与宿主依赖型结合后进入缺陷的偶联。
Retrovirology. 2010 Feb 5;7:9. doi: 10.1186/1742-4690-7-9.
4
Single-round selection yields a unique retroviral envelope utilizing GPR172A as its host receptor.单轮筛选产生了一种独特的逆转录病毒包膜，其利用GPR172A作为宿主受体。
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5848-53. doi: 10.1073/pnas.0809741106. Epub 2009 Mar 23.
5
Effects of the ligand sequence modifications on the retargeted transduction by the retroviral vector having a ligand-chimeric Env protein.配体序列修饰对具有配体嵌合Env蛋白的逆转录病毒载体重新靶向转导的影响。
J Gen Virol. 2008 Dec;89(Pt 12):3137-3143. doi: 10.1099/vir.0.2008/006031-0.
6
Ligand presentation on a synthetic flexible hinge in Moloney murine leukemia virus SU supports entry via a heterologous receptor.莫洛尼鼠白血病病毒SU中合成柔性铰链上的配体呈递支持通过异源受体进入。
Virology. 2007 Jul 5;363(2):303-9. doi: 10.1016/j.virol.2007.01.021. Epub 2007 Feb 28.
7
G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility.G蛋白偶联的APJ受体信号传导诱导粘着斑形成和细胞运动。
Int J Mol Med. 2005 Nov;16(5):787-92.
8
Change of tropism of SL3-2 murine leukemia virus, using random mutational libraries.利用随机突变文库改变SL3-2小鼠白血病病毒的嗜性
J Virol. 2004 Sep;78(17):9343-51. doi: 10.1128/JVI.78.17.9343-9351.2004.
9
The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity.APJ的N端结构域是HIV-1基于中枢神经系统的共受体，对其受体功能和共受体活性至关重要。
Virology. 2003 Dec 5;317(1):84-94. doi: 10.1016/j.virol.2003.08.026.
10
Mutational library analysis of selected amino acids in the receptor binding domain of envelope of Akv murine leukemia virus by conditionally replication competent bicistronic vectors.通过条件性复制活性双顺反子载体对Akv鼠白血病病毒包膜受体结合域中选定氨基酸进行突变文库分析。
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构建一种新型嗜性和野生型复制动力学的γ逆转录病毒，能够使用人 APJ 作为进入受体。

Construction of a gammaretrovirus with a novel tropism and wild-type replication kinetics capable of using human APJ as entry receptor.

机构信息

Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.

出版信息

J Virol. 2012 Oct;86(19):10621-7. doi: 10.1128/JVI.01028-12. Epub 2012 Jul 18.

DOI:10.1128/JVI.01028-12
PMID:22811542
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3457326/
Abstract

We have constructed a replication-competent gammaretrovirus (SL3-AP) capable of using the human G-protein-coupled receptor hAPJ as its entry receptor. The envelope protein of the virus was made by insertion of the 13-amino-acid peptide ligand for hAPJ, flanked by linker sequences, into one of the variable loops of the receptor binding domain of SL3-2, a murine leukemia virus (MLV) that uses the xenotropic-polytropic virus receptor Xpr1 and which has a host range limited to murine cells. This envelope protein can utilize hAPJ as well as murine Xpr1 for entry into host cells with equal efficiencies. In addition, the SL3-AP virus replicates in cells expressing either of its receptors, hAPJ and murine Xpr1, and causes resistance to superinfection and downregulation of hAPJ in infected cells. Thus, SL3-AP is the first example of a retargeted replication-competent retrovirus, with replication characteristics and receptor interference properties similar to those of natural isolates.

摘要

我们构建了一种复制型γ逆转录病毒（SL3-AP），它能够利用人类 G 蛋白偶联受体 hAPJ 作为其进入受体。该病毒的包膜蛋白是通过将 hAPJ 的 13 个氨基酸肽配体插入 SL3-2 的受体结合域的一个可变环中构建的，SL3-2 是一种使用异嗜性-多瘤病毒受体 Xpr1 的鼠白血病病毒（MLV），其宿主范围仅限于鼠细胞。这种包膜蛋白可以利用 hAPJ 和鼠 Xpr1 以相同的效率进入宿主细胞。此外，SL3-AP 病毒在表达其两种受体 hAPJ 和鼠 Xpr1 的细胞中复制，并导致对感染细胞中超感染和 hAPJ 下调的抗性。因此，SL3-AP 是首例经过重定向的复制型逆转录病毒，其复制特征和受体干扰特性与天然分离株相似。