Functional Materials Research Group, Korea Food Research Institute, Gyeonggi 463-746, Republic of Korea.
Food Chem Toxicol. 2012 Oct;50(10):3498-504. doi: 10.1016/j.fct.2012.07.007. Epub 2012 Jul 17.
In this study, we examined the regulatory activity of narirutin fraction from citrus peels on the production of inflammatory mediators managing acute or chronic inflammatory diseases in macrophages. Narirutin fraction inhibited the release, by lipopolysaccharide (LPS)-stimulated macrophages, of nitric oxide (NO) and prostaglandin E2 (PGE2) through suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively. The release, by LPS stimulated macrophages, of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) was also reduced by narirutin fraction in a dose-dependent manner. Furthermore, narirutin fraction inhibited the LPS-mediated activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs), which are signaling molecules involved in production of pro-inflammatory factors. As a result of these properties, narirutin fraction has the potential to be used as a functional dietary supplement and effective anti-inflammatory agent.
在这项研究中，我们研究了柑橘皮中的川陈皮素部分对炎症介质产生的调节作用，以管理巨噬细胞中的急性或慢性炎症性疾病。川陈皮素部分通过抑制诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）的表达，分别抑制了脂多糖（LPS）刺激的巨噬细胞中一氧化氮（NO）和前列腺素 E2（PGE2）的释放。川陈皮素部分还呈剂量依赖性地减少了由 LPS 刺激的巨噬细胞释放白细胞介素-1β（IL-1β）和肿瘤坏死因子-α（TNF-α）。此外，川陈皮素部分抑制了核因子-κB（NF-κB）和丝裂原活化蛋白激酶（MAPKs）的 LPS 介导的激活，这些信号分子参与了促炎因子的产生。由于这些特性，川陈皮素部分有可能被用作功能性膳食补充剂和有效的抗炎剂。
