Ivanova E A, Sarycheva N Yu, Dubynin V A, Malyshev A V, Kalikhevich V N, Ardemasova Z A, Kamensky A A
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia.
Bull Exp Biol Med. 2012 Jun;153(2):177-81. doi: 10.1007/s10517-012-1670-3.
The study examined the effect of an analog to N-terminal nociceptin fragment AcOH×Phe-Gly-Gly-Phe-NH(2) on the behavior of albino rats. This tetrapeptide (5 μg/kg intraperitoneally) significantly enhanced motor and exploratory activity in mature rats and in 42-day pups and produced opposite effects in 21-day rat pups, which attests to the complex dynamics of maturation of nervous structures involved in the realization of nociceptin action.
该研究考察了N端痛敏肽片段AcOH×Phe-Gly-Gly-Phe-NH(2)的类似物对白化大鼠行为的影响。这种四肽（5微克/千克腹腔注射）显著增强了成年大鼠和42日龄幼鼠的运动和探索活动，而对21日龄幼鼠产生了相反的作用，这证明了参与痛敏肽作用实现的神经结构成熟的复杂动态过程。
