School of Engineering and Informatics, National University of Ireland Galway, University Road, Galway, Ireland.
Gait Posture. 2013 Jan;37(1):49-54. doi: 10.1016/j.gaitpost.2012.05.028. Epub 2012 Jul 18.
To investigate the capacity of a single triaxial accelerometer sensor in detecting gait and balance impairments in pre-manifest and manifest Huntington's disease (HD) subjects.
Fourteen manifest HD (MHD) (age: 51.83±14.8), ten pre-manifest HD (PHD) (age: 44.8±11.7) and ten healthy subjects (HLY) (age: 56.4±10.9) were recruited. The sensor was attached to the upper sternum as subjects completed gait and Romberg balance tests. An inverted pendulum model of the body's centre of mass and an unbiased autocorrelation procedure were employed to derive gait parameters from the triaxial accelerometer signal. The accuracy of the gait measurements was compared to those recorded by a computerized walkway.
Strong agreement was seen between the sensor and the walkway; cadence (ICC=0.95, CI=[0.75, 0.97]), velocity (ICC=0.94, CI=[0.75, 0.97]) and step length (ICC=0.89, CI=[0.77, 0.95]). Sensor derived velocity was significantly higher in HLY (p<0.001) and PHD (p<0.005) when compared to MHD. Step and stride length was significantly longer in HLY (p<0.05) and PHD (p<0.001) when compared to MHD. Significant differences between subject groups across all four balance tasks (p<0.001) were found.
An accelerometer based sensor may be an effective means of differentiating between pre-manifest and manifest Huntington's disease subjects.
研究单三轴加速度计传感器在检测前驱期和显性亨廷顿病（HD）患者步态和平衡障碍方面的能力。
招募了 14 名显性 HD（MHD）患者（年龄：51.83±14.8）、10 名前驱期 HD（PHD）患者（年龄：44.8±11.7）和 10 名健康对照者（HLY）（年龄：56.4±10.9）。将传感器附着在上胸部，让受试者完成步态和 Romberg 平衡测试。采用身体质心的倒立摆模型和无偏自相关程序，从三轴加速度计信号中推导出步态参数。将步态测量的准确性与计算机化步道记录的进行了比较。
传感器与步道之间具有很强的一致性；步频（ICC=0.95，CI=[0.75，0.97]）、速度（ICC=0.94，CI=[0.75，0.97]）和步长（ICC=0.89，CI=[0.77，0.95]）。与 MHD 相比，HLY（p<0.001）和 PHD（p<0.005）的传感器衍生速度明显更高。与 MHD 相比，HLY（p<0.05）和 PHD（p<0.001）的步长和步幅明显更长。在所有四项平衡任务中，发现不同组间存在显著差异（p<0.001）。
基于加速度计的传感器可能是区分前驱期和显性亨廷顿病患者的有效手段。
