艾氏剂对两栖动物神经元、肝脏和肌肉组织氧化酶的毒性作用。
Aldrin toxicity on amphibian neuronal, hepatic and muscular tissue oxidative enzymes.
作者信息
Joseph K V, Rao K J
机构信息
Department of Zoology, Sri Venkateswara University, Tirupati, India.
出版信息
Biochem Int. 1990 Oct;22(1):173-7.
PMID:2282077
Abstract
Aldrin toxicity was studied in the brain, liver and muscle of Rana hexadactyla. It was observed that sublethal concentration of aldrin inhibited the activities of SDH, MDH and ICDH while it elevated the activities of LDH and G-6-PDH. The increase and the decrease was progressive with the exposure period. The changes were attributed to the induced toxic effects such as oxygen distress, energy crisis and microstructural changes.
摘要
研究了六指蛙脑、肝脏和肌肉中艾氏剂的毒性。观察到，艾氏剂的亚致死浓度会抑制琥珀酸脱氢酶（SDH）、苹果酸脱氢酶（MDH）和异柠檬酸脱氢酶（ICDH）的活性，同时会提高乳酸脱氢酶（LDH）和葡萄糖-6-磷酸脱氢酶（G-6-PDH）的活性。随着暴露时间的延长，活性的升高和降低呈渐进性变化。这些变化归因于诸如氧应激、能量危机和微观结构变化等诱导毒性效应。
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