Philip G H, Reddy P M, Ramamurthi R
Department of Zoology, Sri Venkateswara University, Tirupati, India.
Biochem Int. 1991 Aug;24(6):1165-71.
Adult mice, Mus booduga were fed orally with bennzenehexachloride (BHC) at a dose of 50 mg/kg body weight every day for 1, 5 and 15 days. Significant decrease in the pyruvate content was observed at all periods of treatment. In support of this increase in lactate content and lactate dehydrogenase (LDH) activity was noticed in all the three tissues. Enzymes of TCA cycle namely isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH) were inhibited suggesting abnormality in mitochondrial oxidative metabolism as a consequence of BHC toxicity.
成年印度沼鼠每天经口给予林丹（BHC），剂量为50毫克/千克体重，持续1天、5天和15天。在所有治疗阶段均观察到丙酮酸含量显著降低。与此相符的是，在所有三个组织中均发现乳酸含量增加以及乳酸脱氢酶（LDH）活性升高。三羧酸循环的酶，即异柠檬酸脱氢酶（ICDH）、琥珀酸脱氢酶（SDH）和苹果酸脱氢酶（MDH）受到抑制，这表明由于BHC毒性导致线粒体氧化代谢异常。
