de Peusner I C, Perec C J, Stefano F J
Naunyn Schmiedebergs Arch Pharmacol. 1979 Sep;308(3):217-21. doi: 10.1007/BF00501385.
Amylase and K+ resease were measured in slices obtained from innervated and sympathetically denervated rat parotid glands. Amylase release induced by noradrenaline was found to be increased after chronic denervation. The postjunctional component of supersensitivity to noradrenaline was evidenced by an increase in the maximal response to this agonist. The maximal response of denervated glands was blocked by propranolol 10(-5) M. On the other hand, chronic denervation did not modify the alpha-adrenoceptor-mediated response, K+ release, either in the presence or in the absence of ouabain. It is concluded that, after sympathetic denervation, postjunctional supersensitivity develops for the beta-adrenoceptor-mediated but not for the alpha-adrenoceptors-mediated effects of noradrenaline.
在取自支配神经和交感神经去神经支配的大鼠腮腺的切片中测量淀粉酶和钾离子的释放。发现慢性去神经支配后，去甲肾上腺素诱导的淀粉酶释放增加。对去甲肾上腺素超敏反应的节后成分表现为对该激动剂最大反应的增加。10(-5)M普萘洛尔可阻断去神经支配腺体的最大反应。另一方面，无论有无哇巴因，慢性去神经支配均未改变α-肾上腺素能受体介导的反应，即钾离子释放。结论是，交感神经去神经支配后，对去甲肾上腺素的β-肾上腺素能受体介导的效应出现节后超敏反应，而对α-肾上腺素能受体介导的效应则未出现。
