Henriksson R, Carlsöö B, Danielsson A, Hellström S, Idahl L A
Eur J Pharmacol. 1982 Feb 26;78(2):195-200. doi: 10.1016/0014-2999(82)90236-9.
Changes in amylase secretion and cyclic AMP accumulation in response to various secretagogues were studied in parotid glands of adult rats subjected to neonatal sympathetic denervation by unilateral excision of the superior cervical ganglion. Denervation decreased the gland content of amylase and both basal and the stimulated levels of cyclic AMP were elevated. The secretory cells of neonatally denervated glands exhibited enhanced maximal enzyme discharge in response to beta-adrenoceptor agonists. However, the selective beta 1-agonist, prenalterol was not effective in this respect whereas an enhanced maximal secretory response to the beta 2-selective agonist, terbutaline, was particularly prominent. DBcAMP was also more efficient in inducing amylase release from the denervated gland. The result of the present study demonstrate that the usual dominance of the beta 1-adrenoceptor subtype in eliciting amylase release is lost, implying that the differentiation of the beta-adrenoceptor into its subtypes is altered by neonatal sympathetic denervation.
通过单侧切除颈上神经节对成年大鼠进行新生期交感神经去支配，研究了腮腺中淀粉酶分泌和环磷酸腺苷（cAMP）积累对各种促分泌剂的反应变化。去神经支配降低了腮腺中淀粉酶的含量，基础cAMP水平和刺激后的cAMP水平均升高。新生期去神经支配的腺体的分泌细胞对β-肾上腺素能受体激动剂表现出增强的最大酶释放。然而，选择性β1-激动剂普瑞特罗在这方面无效，而对β2-选择性激动剂特布他林的最大分泌反应增强尤为显著。二丁酰环磷腺苷（DBcAMP）在诱导去神经支配的腺体释放淀粉酶方面也更有效。本研究结果表明，在引发淀粉酶释放方面通常占主导地位的β1-肾上腺素能受体亚型丧失，这意味着新生期交感神经去支配改变了β-肾上腺素能受体向其亚型的分化。
