Department of Urology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Curr Urol Rep. 2012 Oct;13(5):348-55. doi: 10.1007/s11934-012-0262-0.
The benefit that patients with overactive bladder (OAB) experience with conservative management is an important aspect in the evaluation of this therapy. The first-line options include behavioral interventions, and several techniques are available. Clinical research indicates amelioration of individual symptoms with these techniques, but few studies have shown a positive effect on health-related quality-of-life parameters. After failure of behavioral therapy or in combination with a training program, pharmacological therapy with anticholinergics is the next step. Extensive clinical research into different pharmacological compounds has shown significant effects on the symptomatic elements of OAB. The clinical relevance and the effects on quality-of-life parameters with pharmacological therapy have also been evaluated and show a significant effect on specific aspects. Recently, clinical research in conservative management of patients with OAB has focused more on evaluating patients' perceptions of their condition and the effects of treatment with patient-reported outcome instruments. Future studies should include these tools in the evaluation of any therapy in OAB.
膀胱过度活动症（OAB）患者接受保守治疗所获得的益处是评估这种治疗方法的一个重要方面。一线治疗选择包括行为干预，有多种技术可供选择。临床研究表明，这些技术可改善个体症状，但很少有研究显示对健康相关生活质量参数有积极影响。在行为治疗失败或与训练计划联合使用后，下一个治疗选择是使用抗胆碱能药物进行药物治疗。针对不同药物化合物的广泛临床研究表明，它们对 OAB 的症状元素有显著效果。药物治疗对生活质量参数的临床相关性和效果也进行了评估，显示对特定方面有显著影响。最近，OAB 患者保守治疗的临床研究更加侧重于评估患者对自身病情的看法以及使用患者报告结局工具治疗的效果。未来的研究应在评估 OAB 的任何治疗方法时纳入这些工具。
