Institute of Applied Health Sciences, University of Aberdeen, UK.
Int J Geriatr Psychiatry. 2013 Jan;28(1):75-81. doi: 10.1002/gps.3792. Epub 2012 Jul 22.
We aimed to investigate three reports of a possible role of early parental death in late onset dementia. We tested a multivariate model of risk factors for late onset dementia that included established (female sex, a family history of dementia, APOE ε4) and putative influences (vascular risk factors, years of full-time education, parental ages at death, and childhood IQ) on dementia risk.
We examined contributions of early life and late life risk factors for dementia by using childhood social and family data and blood samples obtained at interview at age about 78 years. In 1997-1999, we recruited 281 subjects without dementia from a 1932 Scottish IQ survey of children born in 1921 and followed them up to 2010 (at age 88). Binary logistic regression and Bayesian structural equation modelling were used to model dementia risk.
Risk of dementia was associated with increasing age from 77 to 88 years, female sex, death of either parent before age 11 and APOE ε4 genotype. Family history of dementia, childhood IQ, years of education and vascular risk factors did not contribute to the model.
Our multivariate models of the possible causes of late onset dementia confirm previous associations of dementia with female sex and APOE ε4 genotype and supports earlier reports of a role for early parental death.
我们旨在调查三则有关早发性父母死亡可能导致晚年痴呆症的报告。我们检验了一个针对晚年痴呆症风险因素的多变量模型，其中包括已确定的（女性、痴呆家族史、APOE ε4）和可能的影响因素（血管风险因素、全日制受教育年限、父母死亡时的年龄以及儿童智商）对痴呆症风险的影响。
我们通过使用在大约 78 岁时的访谈中获得的童年社会和家庭数据以及血液样本，研究了早发性和晚发性痴呆症风险因素对痴呆症的影响。1997-1999 年，我们从一项 1921 年出生的儿童的 1932 年苏格兰智商调查中招募了 281 名无痴呆症的受试者，并对他们进行了随访，直到 2010 年（88 岁）。我们使用二元逻辑回归和贝叶斯结构方程模型来对痴呆症风险进行建模。
痴呆症的风险与年龄从 77 岁增加到 88 岁、女性、父母在 11 岁之前死亡以及 APOE ε4 基因型有关。痴呆家族史、儿童智商、受教育年限和血管风险因素并未对该模型做出贡献。
我们针对晚年痴呆症可能病因的多变量模型证实了以前关于痴呆症与女性和 APOE ε4 基因型有关的关联，并支持了早发性父母死亡可能导致痴呆症的早期报告。
