Adhesion testing of polyurethane matrix patches for transdermal delivery of testosterone.

The 180 degrees peel test was applied to measure adhesion of three experimental polyurethane (PU) matrix patches and one commercial patch, Testopatch, on human volunteers skin. Comparing the results with those measurements on stainless steel or leather, a significant correlation between the leather data and the skin measurements was found. In contrary to results from stainless steel tests, all of the PU patches achieved better adhesion on skin than the commercial patch.