Prescrire Int. 2012 Jun;21(128):152-4.
In Europe, in mid-2011, about 30 cases of dependence, abuse or withdrawal symptoms attributed to pregabalin had been reported to Swedish and French pharmacovigilance centres and the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). About 20 cases of gabapentin addiction were published in detail. The most frequently reported disorders were withdrawal symptoms. More than half of the patients were hospitalised for withdrawal. Cases of excessive increases in the doses of gabapentin or pregabalin, unauthorised routes of administration, and combination with other substances were also reported. Some patients had no known history of substance abuse. In practice, it is better to avoid exposing patients to these risks when the expected benefits are not properly documented. Healthcare professionals should take care to prevent and detect addiction to pregabalin or gabapentin. When necessary, assistance with tapering off the medication should be offered.
2011年年中,在欧洲,瑞典和法国的药物警戒中心以及欧洲药物和药物成瘾监测中心(EMCDDA)已收到约30例与普瑞巴林有关的依赖、滥用或戒断症状报告。约20例加巴喷丁成瘾病例已详细发表。报告最频繁的病症是戒断症状。超过半数患者因戒断而住院。还报告了加巴喷丁或普瑞巴林剂量过度增加、未经授权的给药途径以及与其他物质合用的病例。一些患者并无药物滥用史。实际上,当预期益处未得到充分证实时,最好避免让患者面临这些风险。医疗保健专业人员应注意预防和检测对普瑞巴林或加巴喷丁的成瘾。必要时,应提供逐渐减少用药剂量的帮助。