Departamento de Morfología, Laboratorio de Morfología Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, IPN, México.
Ann N Y Acad Sci. 2012 Jul;1261:72-8. doi: 10.1111/j.1749-6632.2012.06648.x.
Here, the effects of neurointermediate (NIL), anterior (AL), and total hypophysectomy (HYPOX) on ileal mucosa cells and gut-associated lymphoid tissue (GALT) are reported. Compared with the sham-operated (SHAM) rats, the villi height and goblet cells numbers were significantly decreased in all groups. Lamina propria area decreased in AL and HYPOX, but not in NIL animals. CD8(+) but not CD4(+) lymphocytes decreased in the HYPOX and NIL groups. Paneth cells did not change, while IgA cells, IgM cells, and secretory IgA were significantly decreased in all groups. NIL but not AL animals lost significant numbers of IgA cells and secretory IgA. In summary, pituitary hormones exert lobe-specific regulatory effects on the gut and on GALT.
本文报道了神经垂体中间部（NIL）、前叶（AL）和全垂体切除术（HYPOX）对回肠黏膜细胞和肠道相关淋巴组织（GALT）的影响。与假手术（SHAM）大鼠相比，所有组的绒毛高度和杯状细胞数量均显著降低。AL 和 HYPOX 组固有层面积减少，但 NIL 动物没有。HYPOX 和 NIL 组的 CD8(+)而不是 CD4(+)淋巴细胞减少。Paneth 细胞没有变化，而所有组的 IgA 细胞、IgM 细胞和分泌型 IgA 均显著减少。只有 NIL 动物失去了大量的 IgA 细胞和分泌型 IgA。总之，垂体激素对肠道和 GALT 具有特定叶的调节作用。
