Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare-THL, Helsinki, Finland.
J Med Virol. 2012 Sep;84(9):1497-500. doi: 10.1002/jmv.23352.
Saffold viruses (SAFV) have been discovered recently and they are classified into Theilovirus species in genus Cardiovirus in the Picornaviridae family. SAFV, especially those belonging to the genotype 2, have been difficult to propagate in laboratory cell lines. This study describes the successful isolation of an efficiently growing SAFV-2 strain directly from a stool specimen by standard virological methods. The availability of SAFV isolates that can be propagated to high titers is crucial to the future studies on pathogenesis and epidemiology of these novel human viruses.
最近发现了 Saffold 病毒（SAFV），它们被归类为小 RNA 病毒科心脏病毒属的 Theilovirus 种。SAFV，特别是属于 2 型基因型的病毒，在实验室细胞系中难以繁殖。本研究描述了通过标准病毒学方法从粪便标本中直接成功分离出一株高效生长的 SAFV-2 株的情况。获得能够高滴度繁殖的 SAFV 分离株对于这些新型人类病毒的发病机制和流行病学研究至关重要。
