Institute of the Ruhr-University, Bürkle-de-la-Camp-Platz 1, Bochum, Germany.
Adv Exp Med Biol. 2013;755:79-84. doi: 10.1007/978-94-007-4546-9_10.
While numerous cases of immediate-type occupational asthma due to persulfates with positive skin prick test reactions to ammonium persulfate are well documented, few non-immediate type reactions have been described in the literature. We report the case of an atopic worker who developed work-related asthmatic symptoms shortly after he began his job in persulfate production. The diagnosis of asthma was corroborated by methacholine testing. The patient showed a positive patch test reaction to ammonium persulfate, while skin prick test was negative. He presented an isolated late symptomatic airway obstruction after a cumulative dose of 0.6 mg ammonium persulfate administered by a dosimeter method. An immunologic mechanism was demonstrated by a significant increase in exhaled nitric oxide and the number of eosinophils in induced sputum. These findings suggest that isolated late bronchial reactions to persulfates are mediated by eosinophilic inflammatory responses.
虽然已有大量因过硫酸盐导致的速发型职业性哮喘病例，且这些患者的对过硫酸铵的皮肤点刺试验均呈阳性反应，但文献中仅少数描述了非速发型反应。我们报告了一例特应性工人的病例，他在开始从事过硫酸盐生产工作后不久出现了与工作相关的哮喘症状。乙酰甲胆碱测试证实了哮喘的诊断。患者对过硫酸铵的斑贴试验呈阳性反应，而皮肤点刺试验呈阴性。他在通过剂量计法给予累积剂量 0.6 毫克过硫酸铵后出现孤立的迟发性症状性气道阻塞。通过呼出气一氧化氮和诱导痰中嗜酸性粒细胞数量的显著增加证明了免疫机制的存在。这些发现表明，对过硫酸盐的孤立迟发性支气管反应是由嗜酸性粒细胞炎症反应介导的。
