IL-7 receptor α blockade, an off-switch for autoreactive T cells.
作者信息
Boettler Tobias, von Herrath Matthias
机构信息
Department of Internal Medicine II, University Hospital Freiburg, 79106 Freiburg, Germany.
出版信息
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12270-1. doi: 10.1073/pnas.1209749109. Epub 2012 Jul 23.
Abstract
摘要
相似文献
1
IL-7 receptor α blockade, an off-switch for autoreactive T cells.白细胞介素-7受体α阻断，自身反应性T细胞的一个关闭开关。
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12270-1. doi: 10.1073/pnas.1209749109. Epub 2012 Jul 23.
2
Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.抗白细胞介素-7 受体-α通过调节效应 T 细胞功能逆转非肥胖型糖尿病小鼠的 1 型糖尿病。
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12674-9. doi: 10.1073/pnas.1203795109. Epub 2012 Jun 25.
3
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.IL-7 受体阻断通过促进抑制效应/记忆 T 细胞来逆转自身免疫性糖尿病。
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12668-73. doi: 10.1073/pnas.1203692109. Epub 2012 Jun 25.
4
IL-7 promotes T(H)1 development and serum IL-7 predicts clinical response to interferon-β in multiple sclerosis.白细胞介素-7 促进辅助性 T 细胞 1 型发育，且血清白细胞介素-7 可预测多发性硬化症患者对干扰素-β的临床应答。
Sci Transl Med. 2011 Jul 27;3(93):93ra68. doi: 10.1126/scitranslmed.3002400.
5
Shortening the paths to type 1 diabetes mellitus prevention.缩短1型糖尿病预防之路。
Nat Rev Endocrinol. 2021 Feb;17(2):73-74. doi: 10.1038/s41574-020-00450-5.
6
IL-7 uniquely maintains FoxP3(+) adaptive Treg cells that reverse diabetes in NOD mice via integrin-β7-dependent localization.IL-7 通过整合素-β7 依赖性定位，特异性地维持 FoxP3(+)适应性 Treg 细胞，从而逆转 NOD 小鼠的糖尿病。
J Autoimmun. 2011 Nov;37(3):217-27. doi: 10.1016/j.jaut.2011.06.002. Epub 2011 Jul 13.
7
Exploiting differential expression of the IL-7 receptor on memory T cells to modulate immune responses.利用 IL-7 受体在记忆 T 细胞上的差异表达来调节免疫反应。
Cytokine Growth Factor Rev. 2014 Aug;25(4):391-401. doi: 10.1016/j.cytogfr.2014.07.012. Epub 2014 Jul 29.
8
Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms.非肥胖糖尿病小鼠的胰岛移植排斥反应涉及共同γ链以及依赖和不依赖CD28/CD154的机制。
J Immunol. 2003 Oct 1;171(7):3878-85. doi: 10.4049/jimmunol.171.7.3878.
9
Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes.人源化抗白细胞介素-7 受体单克隆抗体 RN168 在 1 型糖尿病患者中的免疫调节活性。
JCI Insight. 2019 Dec 19;4(24):126054. doi: 10.1172/jci.insight.126054.
10
IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis.白细胞介素-7/白细胞介素-7受体信号传导对实验性自身免疫性脑脊髓炎中效应性CD4 + T细胞亚群有不同影响。
J Immunol. 2015 Sep 1;195(5):1974-83. doi: 10.4049/jimmunol.1403135. Epub 2015 Jul 29.
引用本文的文献
1
Advanced Delivery Strategies for Immunotherapy in Type I Diabetes Mellitus.I 型糖尿病的免疫疗法的先进递送策略。
BioDrugs. 2023 May;37(3):331-352. doi: 10.1007/s40259-023-00594-6. Epub 2023 May 13.
2
Antisense modulation of IL7R splicing to control sIL7R expression in human CD4 T cells.反义寡核苷酸调节白细胞介素 7 受体剪接以控制人 CD4 T 细胞中可溶性白细胞介素 7 受体的表达。
RNA. 2022 Aug;28(8):1058-1073. doi: 10.1261/rna.079137.122. Epub 2022 May 25.
3
Regulation of autoreactive CD4 T cells by FoxO1 signaling in CNS autoimmunity.FoxO1 信号在中枢神经系统自身免疫中的作用对自身反应性 CD4 T 细胞的调控。
J Neuroimmunol. 2021 Oct 15;359:577675. doi: 10.1016/j.jneuroim.2021.577675. Epub 2021 Jul 31.
4
Modulation of peripheral T-cell function by interleukin-7 in rheumatoid arthritis.白细胞介素-7对类风湿关节炎外周T细胞功能的调节作用
Arthritis Res Ther. 2014 Dec 23;16(6):511. doi: 10.1186/s13075-014-0511-3.
本文引用的文献
1
Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.抗白细胞介素-7 受体-α通过调节效应 T 细胞功能逆转非肥胖型糖尿病小鼠的 1 型糖尿病。
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12674-9. doi: 10.1073/pnas.1203795109. Epub 2012 Jun 25.
2
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.IL-7 受体阻断通过促进抑制效应/记忆 T 细胞来逆转自身免疫性糖尿病。
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12668-73. doi: 10.1073/pnas.1203692109. Epub 2012 Jun 25.
3
Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.利用基因修饰的乳酸乳球菌在小鼠中恢复抗原特异性耐受逆转自身免疫性糖尿病。
J Clin Invest. 2012 May;122(5):1717-25. doi: 10.1172/JCI60530. Epub 2012 Apr 9.
4
Preexisting autoantibodies predict efficacy of oral insulin to cure autoimmune diabetes in combination with anti-CD3.预先存在的自身抗体可预测口服胰岛素联合抗 CD3 治疗自身免疫性糖尿病的疗效。
Diabetes. 2012 Jun;61(6):1490-9. doi: 10.2337/db11-1304. Epub 2012 Feb 23.
5
IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology.IL-7 通过多种机制克服慢性病毒感染并限制器官病理。
Cell. 2011 Feb 18;144(4):601-13. doi: 10.1016/j.cell.2011.01.011. Epub 2011 Feb 3.
6
Genetics, pathogenesis and clinical interventions in type 1 diabetes.1 型糖尿病的遗传学、发病机制和临床干预。
Nature. 2010 Apr 29;464(7293):1293-300. doi: 10.1038/nature08933.
7
Immunotherapy for the prevention and treatment of type 1 diabetes: optimizing the path from bench to bedside.用于预防和治疗1型糖尿病的免疫疗法：优化从实验室到临床应用的路径。
Diabetes Care. 2009 Oct;32(10):1753-68. doi: 10.2337/dc09-0373.
8
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.辅助性白细胞介素-7可拮抗多种细胞和分子抑制网络，以增强免疫疗法。
Nat Med. 2009 May;15(5):528-36. doi: 10.1038/nm.1953. Epub 2009 Apr 26.
9
CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.CD4 T细胞、淋巴细胞减少与白细胞介素-7在自身免疫多步骤通路中的作用
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2999-3004. doi: 10.1073/pnas.0712135105. Epub 2008 Feb 14.
10
Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice.白细胞介素-7对记忆性CD8 T细胞稳态的影响受小鼠治疗时机的影响。
J Clin Invest. 2008 Mar;118(3):1027-39. doi: 10.1172/JCI32020.
Zotero 插件