Wolthers B G, van der Molen J C, Walrecht H, Hesselmans L F
Central Laboratory for Clinical Chemistry, University Hospital, Groningen, The Netherlands.
Clin Chim Acta. 1990 Dec 14;193(3):113-8. doi: 10.1016/0009-8981(90)90242-k.
Deoxycholic acid and chenodeoxycholic acid were administered alternately to four patients with cerebrotendinous xanthomatosis. During this oral therapy serum cholestanol and urinary bile alcohols were determined. Both showed a marked decrease after the start of the two different therapies. It can be concluded that not only chenodeoxycholic acid but also deoxycholic acid is able to suppress endogenous human bile acid synthesis, which is in accordance with other experiments describing the effect of feeding of various bile acids on endogenous bile acid synthesis.
