Department of Periodontology, School of Dentistry, Pontific Catholic University of Minas Gerais, Belo Horizonte, Brazil.
J Clin Periodontol. 2012 Sep;39(9):879-86. doi: 10.1111/j.1600-051X.2012.01922.x. Epub 2012 Jul 25.
The influence of hyperbaric oxygen therapy (HBOT) on peri-implant bone healing in rats with alloxan-induced type-1 diabetes was studied.
Forty-eight male rats were randomly divided into six groups: (1) healthy rats (HR) that received no HBOT; (2) HR that underwent 10 sessions of HBOT before implant installation; (3) HR that underwent 10 sessions of HBOT after implant installation; (4) rats with induced diabetes (DR) without HBOT; (5) DR that underwent 10 sessions of HBOT before implant installation; (6) DR that underwent 10 sessions of HBOT after implant installation. A screw-shaped titanium implant was inserted into the femur. The animals were killed 28 days after implantation. The percentage of bone-to-implant contact (BIC) within the implant threads was evaluated.
Lower BIC was observed in DR (35.35 ± 18.04) compared with the HR (69.07 ± 09.01) (p = 0.001). However, with HBOT, either before or after implantation, BIC was increased in DR. HBOT before implantation was p = 0.03; HBOT after implantation was p = 0.08. This increase reversed the negative effect of diabetes; therefore, the differences between DR and HR were not significant with HBOT (p ≥ 0.21).
HBOT, either before or after implantation, increased the BIC in DR to the level of HR.
研究高压氧治疗（HBOT）对链脲佐菌素诱导的 1 型糖尿病大鼠种植体周围骨愈合的影响。
48 只雄性大鼠随机分为 6 组：（1）健康大鼠（HR），不接受 HBOT；（2）植入前接受 10 次 HBOT 的 HR；（3）植入后接受 10 次 HBOT 的 HR；（4）未接受 HBOT 的诱导糖尿病大鼠（DR）；（5）植入前接受 10 次 HBOT 的 DR；（6）植入后接受 10 次 HBOT 的 DR。将螺旋形钛种植体插入股骨。植入后 28 天处死动物。评估种植体螺纹内的骨-种植体接触率（BIC）。
DR 的 BIC 明显低于 HR（35.35±18.04 比 69.07±09.01）（p=0.001）。然而，无论是在植入前还是植入后接受 HBOT，DR 的 BIC 均增加。植入前 HBOT 为 p=0.03；植入后 HBOT 为 p=0.08。这种增加逆转了糖尿病的负面影响；因此，DR 和 HR 之间的差异在接受 HBOT 后不再显著（p≥0.21）。
植入前或植入后接受 HBOT 均可增加 DR 的 BIC，使其达到 HR 水平。
