*Department of Ophthalmology, Abant Izzet Baysal University of Medicine, Bolu †Malatya EGM Hayat Hospital, Ophthalmology Clinic, Malatya, Turkey.
J Glaucoma. 2014 Feb;23(2):101-4. doi: 10.1097/IJG.0b013e318264ce7c.
To evaluate the influence of a water-loading test on corneal compensated intraocular pressure (IOPcc) and corneal hysteresis (CH) in young healthy subjects.
Forty healthy adult subjects (20 female and 20 male), with a mean age of 27.55±2.57 years (range, 24 to 35 y), participated in this prospective study. IOPcc and CH were measured for 1 eye from each participant with an Ocular Response Analyser. These measurements were taken before and 10, 20, and 30 minutes after water loading.
Thirty-seven right and 3 left eyes of the 40 subjects fulfilled the study's inclusion criteria. A statistically significant increase in IOPcc was observed between 0 and 10 minutes (P=0.002) and a significant decrease between 10 and 30 minutes (P<0.001). We did not observe any statistically significant changes in CH. The Pearson correlation revealed that there was a weak negative correlation between IOPcc and CH measurements taken at the baseline, 10 minutes, and 30 minutes [r values were -0.275 (P=0.086), -0.369 (P=0.019), and -0.246 (P=0.125), respectively].
This study revealed changes in IOPcc and CH after a water-loading test, but only the change in the IOPcc measurement was statistically significant. The association of changes in IOP and CH identified in this study suggests that IOP changes might alter corneal biomechanical properties.
评估水负荷试验对年轻健康受试者角膜补偿眼压（IOPcc）和角膜滞后（CH）的影响。
本前瞻性研究纳入 40 名健康成年受试者（20 名女性，20 名男性），平均年龄 27.55±2.57 岁（24 至 35 岁）。使用眼反应分析仪对每位受试者的 1 只眼进行 IOPcc 和 CH 测量。这些测量在水负荷前以及水负荷后 10、20 和 30 分钟进行。
40 名受试者中，37 只右眼和 3 只左眼符合本研究纳入标准。在 0 至 10 分钟（P=0.002）和 10 至 30 分钟（P<0.001）之间，IOPcc 观察到有统计学显著的增加。CH 无统计学显著变化。Pearson 相关性分析显示，在基线、10 分钟和 30 分钟时，IOPcc 和 CH 测量值之间存在弱负相关[r 值分别为-0.275（P=0.086）、-0.369（P=0.019）和-0.246（P=0.125）]。
本研究揭示了水负荷试验后 IOPcc 和 CH 的变化，但只有 IOPcc 测量值的变化具有统计学意义。本研究中确定的 IOP 和 CH 变化之间的相关性表明，IOP 变化可能改变角膜生物力学特性。
