Department of Psychosocial Resources, Tom Baker Cancer Centre, Alberta Health Services-Cancer Care Holy Cross Site, 2202 2nd Street SW, Calgary, Alberta, Canada T2S 3C1.
Br J Cancer. 2012 Aug 7;107(4):617-25. doi: 10.1038/bjc.2012.309. Epub 2012 Jul 24.
This randomised controlled trial examined the impact of screening for distress followed by two different triage methods on clinically relevant outcomes over a 12-month period.
Newly diagnosed patients attending a large tertiary cancer centre were randomised to one of the two conditions: (1) screening with computerised triage or (2) screening with personalised triage, both following standardised clinical triage algorithms. Patients completed the Distress Thermometer, Pain and Fatigue Thermometers, the Psychological Screen for Cancer (PSSCAN) Part C and questions on resource utilisation at baseline, 3, 6 and 12 months.
In all, 3133 patients provided baseline data (67% of new patients); with 1709 (54.5%) retained at 12 months (15.4% deceased). Mixed effects models revealed that both groups experienced significant decreases in distress, anxiety, depression, pain and fatigue over time. People receiving personalised triage and people reporting higher symptom burden were more likely to access services, which was subsequently related to greater decreases in distress, anxiety and depression. Women may benefit more from personalised triage, whereas men may benefit more from a computerised triage model.
Screening for distress is a viable intervention that has the potential to decrease symptom burden up to 12 months post diagnosis. The best model of screening may be to incorporate personalised triage for patients indicating high levels of depression and anxiety while providing computerised triage for others.
本随机对照试验研究了在 12 个月的时间内,对困扰进行筛查,然后采用两种不同的分诊方法对临床相关结局的影响。
新诊断的患者在一家大型三级癌症中心就诊,随机分配到以下两种情况之一:(1)采用计算机分诊进行筛查,或(2)采用个性化分诊进行筛查,均遵循标准化临床分诊算法。患者在基线、3 个月、6 个月和 12 个月时完成了《苦恼温度计》、《疼痛和疲劳温度计》、《癌症心理筛查(PSSCAN)C 部分》以及资源利用问题的问卷调查。
共有 3133 名患者提供了基线数据(新患者的 67%);其中 1709 名(54.5%)在 12 个月时保留(15.4%死亡)。混合效应模型显示,两组患者的苦恼、焦虑、抑郁、疼痛和疲劳症状均随时间推移而显著减轻。接受个性化分诊和报告更高症状负担的患者更有可能获得服务,这与苦恼、焦虑和抑郁的显著减轻相关。女性可能从个性化分诊中获益更多,而男性可能从计算机分诊模型中获益更多。
对困扰进行筛查是一种可行的干预措施,有潜力在诊断后 12 个月内减轻症状负担。最好的筛查模式可能是为那些表示有较高抑郁和焦虑水平的患者提供个性化分诊,同时为其他患者提供计算机分诊。