雄激素和雄激素受体在皮肤相关疾病中的作用。
The role of androgen and androgen receptor in skin-related disorders.
机构信息
George Whipple Lab for Cancer Research, Departments of Pathology and Urology and The Wilmot Cancer Center, University of Rochester Medical Center, Box 626, URMC, 601 Elmwood Ave, Rochester, NY 14642, USA.
出版信息
Arch Dermatol Res. 2012 Sep;304(7):499-510. doi: 10.1007/s00403-012-1265-x. Epub 2012 Jul 25.
Abstract
Androgen and androgen receptor (AR) may play important roles in several skin-related diseases, such as androgenetic alopecia and acne vulgaris. Current treatments for these androgen/AR-involved diseases, which target the synthesis of androgens or prevent its binding to AR, can cause significant adverse side effects. Based on the recent studies using AR knockout mice, it has been suggested that AR and androgens play distinct roles in the skin pathogenesis, and AR seems to be a better target than androgens for the treatment of these skin diseases. Here, we review recent studies of androgen/AR roles in several skin-related disorders, including acne vulgaris, androgenetic alopecia and hirsutism, as well as cutaneous wound healing.
摘要
雄激素和雄激素受体 (AR) 在几种与皮肤相关的疾病中可能发挥重要作用，如雄激素性脱发和寻常痤疮。目前针对这些雄激素/AR 相关疾病的治疗方法，靶向雄激素的合成或阻止其与 AR 结合，可能会导致显著的不良反应。基于最近使用 AR 敲除小鼠的研究，已经提出 AR 和雄激素在皮肤发病机制中发挥不同的作用，并且 AR 似乎是治疗这些皮肤疾病的比雄激素更好的靶点。在这里，我们回顾了雄激素/AR 在几种与皮肤相关的疾病中的作用的最新研究，包括寻常痤疮、雄激素性脱发和多毛症，以及皮肤创伤愈合。
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