雄激素和雄激素受体在皮肤相关疾病中的作用。
The role of androgen and androgen receptor in skin-related disorders.
机构信息
George Whipple Lab for Cancer Research, Departments of Pathology and Urology and The Wilmot Cancer Center, University of Rochester Medical Center, Box 626, URMC, 601 Elmwood Ave, Rochester, NY 14642, USA.
出版信息
Arch Dermatol Res. 2012 Sep;304(7):499-510. doi: 10.1007/s00403-012-1265-x. Epub 2012 Jul 25.
Abstract
Androgen and androgen receptor (AR) may play important roles in several skin-related diseases, such as androgenetic alopecia and acne vulgaris. Current treatments for these androgen/AR-involved diseases, which target the synthesis of androgens or prevent its binding to AR, can cause significant adverse side effects. Based on the recent studies using AR knockout mice, it has been suggested that AR and androgens play distinct roles in the skin pathogenesis, and AR seems to be a better target than androgens for the treatment of these skin diseases. Here, we review recent studies of androgen/AR roles in several skin-related disorders, including acne vulgaris, androgenetic alopecia and hirsutism, as well as cutaneous wound healing.
摘要
雄激素和雄激素受体 (AR) 在几种与皮肤相关的疾病中可能发挥重要作用，如雄激素性脱发和寻常痤疮。目前针对这些雄激素/AR 相关疾病的治疗方法，靶向雄激素的合成或阻止其与 AR 结合，可能会导致显著的不良反应。基于最近使用 AR 敲除小鼠的研究，已经提出 AR 和雄激素在皮肤发病机制中发挥不同的作用，并且 AR 似乎是治疗这些皮肤疾病的比雄激素更好的靶点。在这里，我们回顾了雄激素/AR 在几种与皮肤相关的疾病中的作用的最新研究，包括寻常痤疮、雄激素性脱发和多毛症，以及皮肤创伤愈合。
相似文献
1
The role of androgen and androgen receptor in skin-related disorders.
Arch Dermatol Res. 2012 Sep;304(7):499-510. doi: 10.1007/s00403-012-1265-x. Epub 2012 Jul 25.
2
The antiandrogens. When and how they should be used.
Dermatol Clin. 1993 Jan;11(1):65-72.
3
Androgen receptor in hirsutism and acne.
Gynecol Obstet Invest. 1986;22(4):206-11. doi: 10.1159/000298915.
4
Testosterone metabolism in the skin. A review of its function in androgenetic alopecia, acne vulgaris, and idiopathic hirsutism including recent studies with antiandrogens.
Arch Dermatol. 1975 Nov;111(11):1496-1502. doi: 10.1001/archderm.111.11.1496.
5
Cutaneous hyperandrogenism: role of antiandrogen therapy in acne, hirsutism, and androgenetic alopecia.
J Drugs Dermatol. 2013 Nov;12(11):1297-300.
6
Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne.
J Cutan Med Surg. 1998 Jul;3(1):9-15. doi: 10.1177/120347549800300103.
7
Antiandrogens and the skin.
Int J Dermatol. 1978 Apr;17(3):167-79. doi: 10.1111/j.1365-4362.1978.tb06057.x.
8
Androgens in women: Androgen-mediated skin disease and patient evaluation.
J Am Acad Dermatol. 2019 Jun;80(6):1497-1506. doi: 10.1016/j.jaad.2018.08.062. Epub 2018 Oct 10.
9
[Hormones--underestimated problem in dermatology. Part I. Diseases connected with excessive androgenisation].
Pol Merkur Lekarski. 2002 Jun;12(72):539-45.
10
[Acne vulgaris: endocrine aspects].
Ned Tijdschr Geneeskd. 2006 Jun 10;150(23):1281-5.
引用本文的文献
1
Sex Bias in Autoimmunity: New Findings and New Opportunities.
JID Innov. 2025 Jun 20;5(5):100391. doi: 10.1016/j.xjidi.2025.100391. eCollection 2025 Sep.
2
Effect of Androgens on Human Fascia.
Biology (Basel). 2025 Jun 23;14(7):746. doi: 10.3390/biology14070746.
3
New insights into the phenomenon of remissions and relapses in autoimmune diseases and the puzzle of benign autoantibodies in healthy individuals.
Front Immunol. 2025 May 9;16:1522356. doi: 10.3389/fimmu.2025.1522356. eCollection 2025.
4
Global burden of viral skin diseases from 1990 to 2021: a systematic analysis for the global burden of disease study 2021.
Front Public Health. 2025 Feb 19;13:1464372. doi: 10.3389/fpubh.2025.1464372. eCollection 2025.
5
Hair Growth Effect and the Mechanisms of Extract in DHT-Induced Alopecia Mice Model.
Int J Mol Sci. 2024 Oct 22;25(21):11362. doi: 10.3390/ijms252111362.
6
No genetic causal relationship between acne and prostate cancer through Mendelian randomization combined with meta-analysis.
Front Oncol. 2024 Sep 19;14:1460467. doi: 10.3389/fonc.2024.1460467. eCollection 2024.
7
The efficacy of Topical Clascoterone versus systematic spironolactone for treatment of acne vulgaris: A systematic review and network meta-analysis.
PLoS One. 2024 May 30;19(5):e0298155. doi: 10.1371/journal.pone.0298155. eCollection 2024.
8
Metformin: A Potential Treatment for Acne, Hidradenitis Suppurativa and Rosacea.
Acta Derm Venereol. 2023 Dec 11;103:adv18392. doi: 10.2340/actadv.v103.18392.
9
Insulin and the sebaceous gland function.
Front Physiol. 2023 Sep 1;14:1252972. doi: 10.3389/fphys.2023.1252972. eCollection 2023.
10
Photopneumatic Technology for the Treatment of Mild-to-moderate Acne Vulgaris-A Review and Expert Perspectives.
J Clin Aesthet Dermatol. 2023 Jun;16(6 Suppl 2):S3.
本文引用的文献
1
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.
Sci Transl Med. 2012 Mar 21;4(126):126ra34. doi: 10.1126/scitranslmed.3003122.
2
Diet in acne: further evidence for the role of nutrient signalling in acne pathogenesis.
Acta Derm Venereol. 2012 May;92(3):228-31. doi: 10.2340/00015555-1358.
3
Topical eflornithine hydrochloride improves the effectiveness of standard laser hair removal for treating pseudofolliculitis barbae: a randomized, double-blinded, placebo-controlled trial.
J Am Acad Dermatol. 2012 Oct;67(4):694-9. doi: 10.1016/j.jaad.2011.10.029. Epub 2012 Jan 9.
4
Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne).
Arthritis Rheum. 2012 Jun;64(6):2022-7. doi: 10.1002/art.34332. Epub 2011 Dec 12.
5
Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation.
J Biol Chem. 2012 Jan 13;287(3):2090-8. doi: 10.1074/jbc.M111.323303. Epub 2011 Dec 2.
6
Isotretinoin and FoxO1: A scientific hypothesis.
Dermatoendocrinol. 2011 Jul;3(3):141-65. doi: 10.4161/derm.3.3.15331. Epub 2011 Jul 1.
7
Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis.
Clin Exp Dermatol. 2012 Mar;37(2):104-11. doi: 10.1111/j.1365-2230.2011.04186.x. Epub 2011 Oct 10.
8
Androgenetic alopecia in policemen: higher prevalence and different risk factors relative to the general population (KCIS no. 23).
Arch Dermatol Res. 2011 Dec;303(10):753-61. doi: 10.1007/s00403-011-1173-5. Epub 2011 Sep 17.
9
Ethinylestradiol/Chlormadinone acetate for use in dermatological disorders.
Am J Clin Dermatol. 2011 Sep 6;12 Suppl 1(Suppl 1):13-9. doi: 10.2165/1153875-S0-000000000-00000.
10
Androgen receptor coregulators: recruitment via the coactivator binding groove.
Mol Cell Endocrinol. 2012 Apr 16;352(1-2):57-69. doi: 10.1016/j.mce.2011.08.007. Epub 2011 Aug 17.
Zotero 插件