Department of Dermatology, Beijing Friendship hospital, Capital Medical University, Beijing, China.
Clin Exp Dermatol. 2012 Mar;37(2):104-11. doi: 10.1111/j.1365-2230.2011.04186.x. Epub 2011 Oct 10.
Numerous studies have shown an association between polymorphisms in the androgen receptor gene (AR) and the risk for androgenetic alopecia (AGA), but the overall results are still controversial.
To determine, by conducting a meta-analysis, whether the common AR gene polymorphisms confer susceptibility to AGA.
Publications addressing the association between AR gene polymorphisms and risk for AGA were selected from the PubMed, EMBASE and CBMdisc databases. Data were extracted from the studies by two independent reviewers. The meta-analysis was performed using the software programs RevMan (version 5.0.25) and STATA (version 9.2). From these data, odds ratio (OR) with 95% confidence interval (CI) was calculated.
Only eight studies were found, reporting a total of 2074 patients with AGA and 1115 healthy controls. Three common polymorphisms of the AR gene were addressed: a StuI restriction-site polymorphism (rs6152, G>A), and CAG and GGC triplet-repeat polymorphisms. Meta-analysis results identified a significant association between the G allele of the AR StuI polymorphism and the risk for AGA (OR = 2.68, 95% CI 1.71-4.19, P < 0.01), especially in white populations (OR = 2.76, 95% CI 1.71-4.45, P < 0.01). No association was found between the CAG or GGC polymorphism and the risk for AGA (OR = 0.81, 95% CI 0.49-1.34, P = 0.41; OR = 1.01, 95% CI 0.47-2.14, P = 0.99, respectively).
Our meta-analysis suggests that the G allele of AR StuI polymorphism might be a potential risk factor for AGA, especially in white populations. However, we did not find any obvious association of the CAG and GGC triplet-repeat polymorphisms of the AR gene with risk for AGA.
大量研究表明，雄激素受体（AR）基因多态性与雄激素性脱发（AGA）的风险之间存在关联，但总体结果仍存在争议。
通过荟萃分析确定常见的 AR 基因多态性是否与 AGA 的易感性相关。
从 PubMed、EMBASE 和 CBMdisc 数据库中选择了探讨 AR 基因多态性与 AGA 风险之间关系的出版物。由两名独立的审查员从研究中提取数据。使用 RevMan（版本 5.0.25）和 STATA（版本 9.2）软件程序进行荟萃分析。从这些数据中计算了比值比（OR）及其 95%置信区间（CI）。
仅发现八项研究，共纳入 2074 例 AGA 患者和 1115 例健康对照者。分析了 AR 基因的三个常见多态性：StuI 限制性内切酶多态性（rs6152，G>A）以及 CAG 和 GGC 三核苷酸重复多态性。荟萃分析结果表明，AR StuI 多态性的 G 等位基因与 AGA 的风险之间存在显著关联（OR=2.68，95%CI 1.71-4.19，P<0.01），尤其是在白种人群中（OR=2.76，95%CI 1.71-4.45，P<0.01）。CAG 或 GGC 多态性与 AGA 的风险之间没有关联（OR=0.81，95%CI 0.49-1.34，P=0.41；OR=1.01，95%CI 0.47-2.14，P=0.99）。
本荟萃分析表明，AR StuI 多态性的 G 等位基因可能是 AGA 的潜在危险因素，尤其是在白种人群中。然而，我们没有发现 AR 基因的 CAG 和 GGC 三核苷酸重复多态性与 AGA 风险之间存在明显关联。
