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一种新型强效 Fas 激动剂，可选择性清除造血移植中的肿瘤细胞。

A novel potent Fas agonist for selective depletion of tumor cells in hematopoietic transplants.

出版信息

Blood Cancer J. 2011 Dec;1(12):e47. doi: 10.1038/bcj.2011.47. Epub 2011 Dec 9.

DOI:10.1038/bcj.2011.47
PMID:22829095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3255509/
Abstract

There remains a clear need for effective tumor cell purging in autologous stem cell transplantation (ASCT) where residual malignant cells within the autograft contribute to disease relapse. Here we propose the use of a novel Fas agonist with potent pro-apoptotic activity, termed MegaFasL, as an effective ex-vivo purging agent. MegaFasL selectively kills hematological cancer cells from lymphomas and leukemias and prevents tumor development at concentrations that do not reduce the functional capacity of human hematopoietic stem/progenitor cells both in in vitro and in in vivo transplantation models. These findings highlight the potential use of MegaFasL as an ex-vivo purging agent in ASCT.

摘要

在自体造血干细胞移植 (ASCT) 中，仍然需要有效的肿瘤细胞清除，因为移植物内残留的恶性细胞会导致疾病复发。在这里，我们提出使用一种新型 Fas 激动剂，称为 MegaFasL，作为有效的体外净化剂。MegaFasL 选择性地杀死淋巴瘤和白血病中的血液癌细胞，并在不降低人造血干/祖细胞功能能力的浓度下防止肿瘤发展，无论是在体外还是体内移植模型中。这些发现强调了 MegaFasL 作为 ASCT 中体外净化剂的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e06/3255509/1dc96ed7b79b/bcj201147f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e06/3255509/fbd707c60c34/bcj201147f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e06/3255509/f08bf20b9c46/bcj201147f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e06/3255509/1dc96ed7b79b/bcj201147f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e06/3255509/fbd707c60c34/bcj201147f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e06/3255509/f08bf20b9c46/bcj201147f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e06/3255509/1dc96ed7b79b/bcj201147f3.jpg

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