Schmid V, Plickert G
Zoological Institute, University of Basel, Switzerland.
Differentiation. 1990 Aug;44(2):95-102. doi: 10.1111/j.1432-0436.1990.tb00542.x.
The effect of proportion altering factor (PAF) on the transdifferentiation of isolated striated muscle into RFamide-positive nerve cells was investigated. The factor reduces incorporation of 3H-thymidine into replicating DNA; the effect is concentration-dependent and reversible. Transdifferentiation to nerve cells increases by up to 60% if PAF is applied shortly before or at the time of initiation of DNA synthesis. When treatment was terminated 4 h before the start of S-phase or when PAF was applied at the peak of S-phase no increase in nerve cell formation was observed.
