Lorenzini C A, Bucherelli C, Giachetti A, Tassoni G
Department of Physiological Sciences, University of Florence, Italy.
Funct Neurol. 1990 Jul-Sep;5(3):267-71.
Conditioned initial freezing duration was timed in the light-dark box test. Four genetically diverse groups of rats (Wistar, Long Evans, Brattleboro heterozigous for diabetes insipidus, Brattleboro homozygous for diabetes insipidus) were employed. 0.6 mA and 1.8 mA footshocks were administered as nociceptive stressors. The results showed that freezing duration easily and conveniently measures the animal's capacity of responding to stress. This finding is discussed in terms of genetically determined hormonal make-up and of CNS receptorial mechanisms. Initial freezing duration is proposed as a tool to evaluate stress responses.
在明暗箱试验中记录条件性初始冻结持续时间。使用了四组基因不同的大鼠（Wistar大鼠、Long Evans大鼠、遗传性尿崩症杂合的Brattleboro大鼠、遗传性尿崩症纯合的Brattleboro大鼠）。给予0.6 mA和1.8 mA的足部电击作为伤害性应激源。结果表明，冻结持续时间能够轻松便捷地衡量动物对应激的反应能力。从基因决定的激素组成和中枢神经系统感受机制方面对这一发现进行了讨论。建议将初始冻结持续时间作为评估应激反应的一种工具。
